Literature DB >> 27565337

The Whole (Cell) Is Less Than the Sum of Its Parts.

Jonathan G Van Vranken1, Jared Rutter2.   

Abstract

Despite advances in metabolite profiling, a full picture of the metabolic landscape of the cell has been limited by sub-cellular compartmentalization, which segregates distinct nutrient pools into membrane-bound organelles. Now, Chen et al. describe methods for overcoming this hurdle and provide a new quantitative picture of the mitochondrial metabolome.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Year:  2016        PMID： 27565337      PMCID： PMC5260058          DOI： 10.1016/j.cell.2016.08.011

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  7 in total

1.  Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.

Authors:  M P King; G Attardi
Journal:  Science       Date:  1989-10-27       Impact factor: 47.728

Review 2.  Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

Authors:  A King; M A Selak; E Gottlieb
Journal:  Oncogene       Date:  2006-08-07       Impact factor: 9.867

3.  Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.

Authors:  Walter W Chen; Elizaveta Freinkman; Tim Wang; Kıvanç Birsoy; David M Sabatini
Journal:  Cell       Date:  2016-08-25       Impact factor: 41.582

4.  Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.

Authors:  Lucas B Sullivan; Dan Y Gui; Aaron M Hosios; Lauren N Bush; Elizaveta Freinkman; Matthew G Vander Heiden
Journal:  Cell       Date:  2015-07-30       Impact factor: 41.582

5.  An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Authors:  Kıvanç Birsoy; Tim Wang; Walter W Chen; Elizaveta Freinkman; Monther Abu-Remaileh; David M Sabatini
Journal:  Cell       Date:  2015-07-30       Impact factor: 41.582

Review 6.  Hallmarks of a new era in mitochondrial biochemistry.

Authors:  David J Pagliarini; Jared Rutter
Journal:  Genes Dev       Date:  2013-12-15       Impact factor: 11.361

7.  Reductive carboxylation supports redox homeostasis during anchorage-independent growth.

Authors:  Lei Jiang; Alexander A Shestov; Pamela Swain; Chendong Yang; Seth J Parker; Qiong A Wang; Lance S Terada; Nicholas D Adams; Michael T McCabe; Beth Pietrak; Stan Schmidt; Christian M Metallo; Brian P Dranka; Benjamin Schwartz; Ralph J DeBerardinis
Journal:  Nature       Date:  2016-04-06       Impact factor: 49.962
  7 in total
  4 in total

1.  Probing mitochondrial metabolism in vivo.

Authors:  Gregory S McElroy; Navdeep S Chandel
Journal:  Proc Natl Acad Sci U S A       Date:  2018-12-18       Impact factor: 11.205

2.  Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites.

Authors:  Walter W Chen; Elizaveta Freinkman; David M Sabatini
Journal:  Nat Protoc       Date:  2017-09-29       Impact factor: 13.491

Review 3.  Exosome Carrier Effects; Resistance to Digestion in Phagolysosomes May Assist Transfers to Targeted Cells; II Transfers of miRNAs Are Better Analyzed via Systems Approach as They Do Not Fit Conventional Reductionist Stoichiometric Concepts.

Authors:  Philip W Askenase
Journal:  Int J Mol Sci       Date:  2022-05-31       Impact factor: 6.208

4.  Metabolic profiling of isolated mitochondria and cytoplasm reveals compartment-specific metabolic responses.

Authors:  Daqiang Pan; Caroline Lindau; Simon Lagies; Nils Wiedemann; Bernd Kammerer
Journal:  Metabolomics       Date:  2018-03-31       Impact factor: 4.290
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.