Literature DB >> 27563160

A Dielectric Rod Antenna for Picosecond Pulse Stimulation of Neurological Tissue.

Ross A Petrella1, Karl H Schoenbach1, Shu Xiao1.   

Abstract

A dielectrically loaded wideband rod antenna has been studied as a pulse delivery system to subcutaneous tissues. Simulation results applying 100 ps electrical pulse show that it allows us to generate critical electric field for biological effects, such as brain stimulation, in the range of several centimeters. In order to reach the critical electric field for biological effects, which is approximately 20 kV/cm, at a depth of 2 cm, the input voltage needs to be 175 kV. The electric field spot size in the brain at this position is approximately 1 cm2. Experimental studies in free space with a conical antenna (part of the antenna system) with aluminum nitride as the dielectric have confirmed the accuracy of the simulation. These results set the foundation for high voltage in situ experiments on the complete antenna system and the delivery of pulses to biological tissue.

Entities:  

Keywords:  Ultrawideband antennas; dielectric loaded antennas; picoseconds pulses

Year:  2016        PMID: 27563160      PMCID: PMC4993468          DOI: 10.1109/TPS.2016.2537213

Source DB:  PubMed          Journal:  IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc        ISSN: 0093-3813            Impact factor:   1.222


  4 in total

1.  Simulation study of delivery of subnanosecond pulses to biological tissues with an impulse radiating antenna.

Authors:  Fei Guo; Chenguo Yao; Chandra Bajracharya; Swetha Polisetty; Karl H Schoenbach; Shu Xiao
Journal:  Bioelectromagnetics       Date:  2013-11-06       Impact factor: 2.010

2.  Dielectric properties of brain tissue between 0.01 and 10 GHz.

Authors:  K R Foster; J L Schepps; R D Stoy; H P Schwan
Journal:  Phys Med Biol       Date:  1979-11       Impact factor: 3.609

3.  Electric field depth-focality tradeoff in transcranial magnetic stimulation: simulation comparison of 50 coil designs.

Authors:  Zhi-De Deng; Sarah H Lisanby; Angel V Peterchev
Journal:  Brain Stimul       Date:  2012-03-21       Impact factor: 8.955

4.  Cell stimulation and calcium mobilization by picosecond electric pulses.

Authors:  Iurii Semenov; Shu Xiao; Dongkoo Kang; Karl H Schoenbach; Andrei G Pakhomov
Journal:  Bioelectrochemistry       Date:  2015-05-20       Impact factor: 5.373

  4 in total
  2 in total

1.  3D bioprinter applied picosecond pulsed electric fields for targeted manipulation of proliferation and lineage specific gene expression in neural stem cells.

Authors:  Ross A Petrella; Peter A Mollica; Martina Zamponi; John A Reid; Shu Xiao; Robert D Bruno; Patrick C Sachs
Journal:  J Neural Eng       Date:  2018-05-31       Impact factor: 5.379

Review 2.  Does the shape of the electric pulse matter in electroporation?

Authors:  Vitalij Novickij; Nina Rembiałkowska; Wojciech Szlasa; Julita Kulbacka
Journal:  Front Oncol       Date:  2022-09-14       Impact factor: 5.738

  2 in total

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