Literature DB >> 27561486

Polysaccharides purified from Cordyceps cicadae protects PC12 cells against glutamate-induced oxidative damage.

Opeyemi J Olatunji1, Yan Feng1, Oyenike O Olatunji2, Jian Tang1, Yuan Wei1, Zhen Ouyang3, Zhaoliang Su4.   

Abstract

Two polysaccharides CPA-1 and CPB-2 were isolated purified from Cordyceps cicadae by hot water extraction, ethanol precipitation and purification using anion exchange and gel filtration chromatography. Preliminary structural characterization of CPA-1 and CPB-2 were performed. The protective effect of CPA-1 and CPB-2 against glutamate-induced oxidative toxicity in PC12 cells was analyzed. The results indicated that pretreatment of PC12 cells with CPA-1 and CPB-2 significantly increased cell survival, Ca(2+) overload and ROS generation. CPA-1 and CPB-2 also markedly up-regulated the antioxidant status of pretreated PC12 cells. Our results suggested that Cordyceps cicadae polysaccharides can protect PC12 cells against glutamate excitotoxicity and might serve as therapeutic agents for neuronal disorders.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cordyceps cicadae; Glutamate; Neuroprotection; PC12 cells; Polysaccharide

Mesh：

Substances：

Year:  2016        PMID： 27561486     DOI： 10.1016/j.carbpol.2016.06.108

Source DB:  PubMed          Journal:  Carbohydr Polym        ISSN： 0144-8617            Impact factor:   9.381


  8 in total

1.  Extraction, Purification, Physicochemical Properties, and Activity of a New Polysaccharide From Cordyceps cicadae.

Authors:  Zizhong Tang; Wenjie Lin; Yusheng Chen; Shiling Feng; Yihan Qin; Yirong Xiao; Hong Chen; Yuntao Liu; Hui Chen; Tongliang Bu; Qinfeng Li; Yi Cai; Huipeng Yao; Chunbang Ding
Journal:  Front Nutr       Date:  2022-06-09

Review 2.  Polysaccharide-Based Transdermal Drug Delivery.

Authors:  Jingyuan Li; Hong Xiang; Qian Zhang; Xiaoqing Miao
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-14

3.  Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the Seaweed Caulerpa racemosa in High Fructose-Streptozotocin Induced Diabetic Nephropathy.

Authors:  Meng Cao; Yan Li; Ademola C Famurewa; Opeyemi Joshua Olatunji
Journal:  Diabetes Metab Syndr Obes       Date:  2021-05-12       Impact factor: 3.168

4.  Characterization and anti-tumor activity of a polysaccharide isolated from Dendrobium officinale grown in the Huoshan County.

Authors:  Yuan Wei; Linwei Wang; Dujun Wang; Dan Wang; Chongwei Wen; Bangxin Han; Zhen Ouyang
Journal:  Chin Med       Date:  2018-09-10       Impact factor: 5.455

5.  The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and its Mechanism: An Investigation Using Network Pharmacology-Based Analysis.

Authors:  Dahae Lee; Won-Yung Lee; Kiwon Jung; Yong Sam Kwon; Daeyoung Kim; Gwi Seo Hwang; Chang-Eop Kim; Sullim Lee; Ki Sung Kang
Journal:  Biomolecules       Date:  2019-08-26

6.  Effects of supplemented culture media from solid-state fermented Isaria cicadae on performance, serum biochemical parameters, serum immune indexes, antioxidant capacity and meat quality of broiler chickens.

Authors:  Shaoshuai Liu; Wenjuan Yan; Chang Ma; Yajing Liu; Limin Gong; Crystal Levesque; Bing Dong
Journal:  Asian-Australas J Anim Sci       Date:  2019-08-03       Impact factor: 2.509

7.  Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice.

Authors:  Yi Zheng; Shiying Li; Chuang Li; Ying Shao; Anhui Chen
Journal:  Foods       Date:  2022-02-11

Review 8.  Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases.

Authors:  Manel Dhahri; Mawadda Alghrably; Hamdoon A Mohammed; Syed Lal Badshah; Noreen Noreen; Fouzi Mouffouk; Saleh Rayyan; Kamal A Qureshi; Danish Mahmood; Joanna Izabela Lachowicz; Mariusz Jaremko; Abdul-Hamid Emwas
Journal:  Pharmaceutics       Date:  2021-12-21       Impact factor: 6.321
  8 in total

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