Literature DB >> 27560192

Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.

Robert B Cameron1,2, Craig C Beeson1, Rick G Schnellmann1,2.   

Abstract

Mitochondria have various roles in cellular metabolism and homeostasis. Because mitochondrial dysfunction is associated with many acute and chronic degenerative diseases, mitochondrial biogenesis (MB) is a therapeutic target for treating such diseases. Here, we review the role of mitochondrial dysfunction in acute and chronic degenerative diseases and the cellular signaling pathways by which MB is induced. We then review existing work describing the development and application of drugs that induce MB in vitro and in vivo. In particular, we discuss natural products and modulators of transcription factors, kinases, cyclic nucleotides, and G protein-coupled receptors.

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Year:  2016        PMID： 27560192      PMCID： PMC5564430          DOI： 10.1021/acs.jmedchem.6b00669

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  322 in total

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4.  Effect of rosiglitazone on cardiac electrophysiology, infarct size and mitochondrial function in ischaemia and reperfusion of swine and rat heart.

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5.  Rosiglitazone improves pancreatic mitochondrial function in an animal model of dysglycemia: role of the insulin-like growth factor axis.

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6.  Metoprolol represses PGC1alpha-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart.

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7.  Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury.

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Journal:  PLoS One       Date:  2009-02-26       Impact factor: 3.240
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  22 in total

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Review 2.  Mitochondrial energetics in the kidney.

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Review 5.  Mitochondrial-Based Therapeutics for the Treatment of Spinal Cord Injury: Mitochondrial Biogenesis as a Potential Pharmacological Target.

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Review 7.  Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases.

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8.  The 5-hydroxytryptamine receptor 1F stimulates mitochondrial biogenesis and angiogenesis in endothelial cells.

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Review 10.  Targeting Mitochondrial Biogenesis with Polyphenol Compounds.

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