Ouarda Taleb-Belkadi1, Hadjer Chaib1, Lakhdar Zemour2, Azzedine Fatah3, Belkacem Chafi4, Khedidja Mekki1. 1. a Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences de la Nature et de la Vie , Université d'Oran 1 Ahmed Benbella , Oran , Algérie. 2. b Service d'épidémiologie, Etablissement Hospitalier Universitaire Oran , Oran , Algérie. 3. c Direction de la santé et de la population d'Oran , Oran , Algérie , and. 4. d Service de Maternité. Etablissement Hospitalier Universitaire Oran , Oran , Algérie.
Abstract
OBJECTIVE: To evaluate the effect of perimenopause and postmenopause on lipid profile, inflammation, and oxidative stress in women. METHODS: This cross-sectional study included 117 women (47 ± 6 years) classified as perimenopausal (n = 47), postmenopausal (n = 40), or non-menopausal (n = 30). In serum, we analyzed lipid profile, tumor necrosis factor-alpha (TNF-α), interleukin-1α (IL-1α), and C-reactive protein (CRP). Pro-oxidant status was assessed by thiobarbituric acid reactive substances (TBARS) and protein carbonyls. Antioxidant defense was performed by analysis of superoxide dismutase (SOD) and catalase activities. RESULTS: Compared to non-menopausal women, triacylglycerols (TG) were similar, total cholesterol and LDL-C were higher in perimenopausal and postmenopausal women, while HDL-C concentrations were decreased. TNF-α and IL-1α were higher in postmenopausal women, while CRP concentrations were elevated in both peri-and postmenopausal women (p < 0.05). TBARS and carbonyls were increased in peri- and postmenopausal women (p < 0.05). SOD and CAT activities were decreased in postmenopausal women (p < 0.05) and elevated in perimenopausal women. CONCLUSION: Menopausal transition and postmenopause were associated with dyslipidemia, inflammation, and unbalanced oxidative status exposing women to cardiovascular risk.
OBJECTIVE: To evaluate the effect of perimenopause and postmenopause on lipid profile, inflammation, and oxidative stress in women. METHODS: This cross-sectional study included 117 women (47 ± 6 years) classified as perimenopausal (n = 47), postmenopausal (n = 40), or non-menopausal (n = 30). In serum, we analyzed lipid profile, tumor necrosis factor-alpha (TNF-α), interleukin-1α (IL-1α), and C-reactive protein (CRP). Pro-oxidant status was assessed by thiobarbituric acid reactive substances (TBARS) and protein carbonyls. Antioxidant defense was performed by analysis of superoxide dismutase (SOD) and catalase activities. RESULTS: Compared to non-menopausal women, triacylglycerols (TG) were similar, total cholesterol and LDL-C were higher in perimenopausal and postmenopausal women, while HDL-C concentrations were decreased. TNF-α and IL-1α were higher in postmenopausal women, while CRP concentrations were elevated in both peri-and postmenopausal women (p < 0.05). TBARS and carbonyls were increased in peri- and postmenopausal women (p < 0.05). SOD and CAT activities were decreased in postmenopausal women (p < 0.05) and elevated in perimenopausal women. CONCLUSION: Menopausal transition and postmenopause were associated with dyslipidemia, inflammation, and unbalanced oxidative status exposing women to cardiovascular risk.
Authors: Lindsay D Strehle; Kathryn L G Russart; Valerie A Burch; Corena V Grant; Leah M Pyter Journal: Am J Physiol Regul Integr Comp Physiol Date: 2022-08-22 Impact factor: 3.210
Authors: Jéssica S Giolo; Juliene G Costa; Jair P da Cunha-Junior; Ana Cláudia A M Pajuaba; Ernesto A Taketomi; Adriele V de Souza; Douglas C Caixeta; Leonardo G Peixoto; Erick P de Oliveira; Sarah Everman; Foued S Espindola; Guilherme M Puga Journal: Nutrients Date: 2018-03-29 Impact factor: 5.717