| Literature DB >> 2755874 |
Abstract
The pharmacological effects of guinea pig vasoactive intestinal peptide (VIP) were studied in isolated perfused guinea pig hearts. Bolus injections of VIP produced a dose-dependent tachycardia that was not affected by atenolol. A decrease in amplitude of ventricular contractions occurred in response to all doses of VIP. This response was preceded by a small increase in amplitude in 3 of 6 hearts at the highest dose. VIP produced a decrease in perfusion pressure which was prominent after coronary tone was elevated with [Arg8]-vasopressin. The present findings support speculation that VIP may have a role in the regulation of heart rate and coronary blood flow.Entities:
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Year: 1989 PMID： 2755874 DOI： 10.1016/0196-9781(89)90041-7
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750