Literature DB >> 27558587

Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats.

Nobuaki Egashira1, Hikari Iba2, Haruna Kuwano2, Rikako Kawanaka2, Masaki Nagao2, Hiroshi Moriyama2, Takuya Watanabe2, Kaori Kubota3, Shutaro Katsurabayashi2, Katsunori Iwasaki3.   

Abstract

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30-300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.
Copyright © 2016 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Conditioned fear stress; Kamishoyosan; Ovariectomized rats

Mesh：

Substances：

Year:  2016        PMID： 27558587     DOI： 10.1016/j.jphs.2016.07.007

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  6 in total

Review 1.  Estrogenic hormones receptors in Alzheimer's disease.

Authors:  Angeles C Tecalco-Cruz; Jesús Zepeda-Cervantes; Bibiana Ortega-Domínguez
Journal:  Mol Biol Rep       Date:  2021-10-16       Impact factor: 2.316

2.  A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Investigate the Effects of Kamishoyosan, a Traditional Japanese Medicine, on Menopausal Symptoms: The KOSMOS Study.

Authors:  Kiyoshi Takamatsu; Mariko Ogawa; Satoshi Obayashi; Takashi Takeda; Masakazu Terauchi; Tsuyoshi Higuchi; Kiyoko Kato; Toshiro Kubota
Journal:  Evid Based Complement Alternat Med       Date:  2021-02-26       Impact factor: 2.629

Review 3.  Structural, functional, and behavioral significance of sex and gonadal hormones in the basolateral amygdala: A review of preclinical literature.

Authors:  Michaela E Price; Brian A McCool
Journal:  Alcohol       Date:  2021-08-06       Impact factor: 2.405

4.  Effects of Kamishoyosan, a Traditional Japanese Medicine, on Menopausal Symptoms: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.

Authors:  Kiyoshi Takamatsu; Mariko Ogawa; Tsuyoshi Higuchi; Takashi Takeda; Kunihiko Hayashi; Hideki Mizunuma
Journal:  Evid Based Complement Alternat Med       Date:  2020-07-11       Impact factor: 2.629

5.  Antidepressive Effects of Kamishoyosan through 5-HT1AReceptor and PKA-CREB-BDNF Signaling in the Hippocampus in Postmenopausal Depression-Model Mice.

Authors:  Shoko Shimizu; Yugo Ishino; Takashi Takeda; Masaya Tohyama; Shingo Miyata
Journal:  Evid Based Complement Alternat Med       Date:  2019-11-03       Impact factor: 2.629

6.  An Herbal Formulation of Jiawei Xiaoyao for the Treatment of Functional Dyspepsia: A Multicenter, Randomized, Placebo-Controlled, Clinical Trial.

Authors:  Guang Chen; Peimin Feng; Shaofeng Wang; Xiangping Ding; Jiaying Xiong; Jianhua Wu; Lihua Wang; Wei Chen; Guixia Chen; Mei Han; Ting Zou; Lei Li; Hongbo Du
Journal:  Clin Transl Gastroenterol       Date:  2020-10       Impact factor: 4.396
  6 in total

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