| Literature DB >> 27558125 |
Katia Monteleone1, Giuseppe Corano Scheri1, Maura Statzu1, Carla Selvaggi1, Francesca Falasca1, Noemi Giustini2, Ivano Mezzaroma3, Ombretta Turriziani1, Gabriella d'Ettorre2, Guido Antonelli1, Carolina Scagnolari4.
Abstract
This study aimed to evaluate the association between the IFNL4 rs368234815 (ΔG/TT) dinucleotide polymorphism and the IFN response during chronic HIV-1 infection. We carried out genotyping analysis and measured the expression of IFN-stimulated genes (ISGs) (myxovirus resistance protein A [MxA], ISG15, ISG56, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like [APOBEC] 3F and APOBEC3G) on peripheral blood mononuclear cells collected from naïve and HAART-treated HIV-1-infected patients. There were no statistically significant differences in endogenous ISGs mRNA levels among HIV-1-positive patients bearing different IFNL4 genotypes, suggesting that ISG expression is independent of the IFNL4 genotype in HIV-1 infection.Entities:
Keywords: HIV-1; IFN; IFNL4; ISGs; SNP
Mesh：
Substances：
Year: 2016 PMID： 27558125 DOI： 10.1007/s00705-016-3016-3
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574