Literature DB >> 27557418

Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis.

Yan Li1, Qun Yue1, Nicole M Krausert2, Zhiqiang An1, James B Gloer2, Gerald F Bills1.   

Abstract

Eleven emestrin-type epipolythiodioxopiperazines, including four new compounds, emestrins H-K (1-4), were isolated from the crude extracts of two strains of the coprophilous fungus Podospora australis. The structures of 1-4 were established primarily by analysis of NMR data, and the absolute configuration of C-6 in 1 was independently assigned using the modified Mosher method. Four of the known emestrins obtained (emestrins C-E and MPC1001C) were found to selectively inhibit the growth of Cryptococcus neoformans. These results also represent the first report of chemistry from any strain of P. australis.

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Year:  2016        PMID： 27557418     DOI： 10.1021/acs.jnatprod.6b00498

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.

Authors:  Nicole M Dischler; Lijian Xu; Yan Li; Connie B Nichols; J Andrew Alspaugh; Gerald F Bills; James B Gloer
Journal:  J Nat Prod       Date:  2019-03-07       Impact factor: 4.050

2.  Anti-Cryptococcus Phenalenones and Cyclic Tetrapeptides from Auxarthron pseudauxarthron.

Authors:  Yan Li; Qun Yue; Dinith R Jayanetti; Dale C Swenson; Geoffrey A Bartholomeusz; Zhiqiang An; James B Gloer; Gerald F Bills
Journal:  J Nat Prod       Date:  2017-06-28       Impact factor: 4.050

3.  Chemometrics and genome mining reveal an unprecedented family of sugar acid-containing fungal nonribosomal cyclodepsipeptides.

Authors:  Chen Wang; Dongliang Xiao; Baoqing Dun; Miaomiao Yin; Adigo Setargie Tsega; Linan Xie; Wenhua Li; Qun Yue; Sibao Wang; Han Gao; Min Lin; Liwen Zhang; István Molnár; Yuquan Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-01       Impact factor: 12.779

4.  Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay.

Authors:  Lijian Xu; Yan Li; John B Biggins; Brian R Bowman; Gregory L Verdine; James B Gloer; J Andrew Alspaugh; Gerald F Bills
Journal:  Appl Microbiol Biotechnol       Date:  2018-02-02       Impact factor: 4.813

Review 5.  Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community.

Authors:  Huzefa A Raja; Andrew N Miller; Cedric J Pearce; Nicholas H Oberlies
Journal:  J Nat Prod       Date:  2017-02-15       Impact factor: 4.050

Review 6.  Structural Diversity and Biological Activities of the Cyclodipeptides from Fungi.

Authors:  Xiaohan Wang; Yuying Li; Xuping Zhang; Daowan Lai; Ligang Zhou
Journal:  Molecules       Date:  2017-11-23       Impact factor: 4.411

7.  Anti-cryptococcal activity of preussolides A and B, phosphoethanolamine-substituted 24-membered macrolides, and leptosin C from coprophilous isolates of Preussia typharum.

Authors:  Bruno Perlatti; Nan Lan; Meichun Xiang; Cody E Earp; Joseph E Spraker; Colin J B Harvey; Connie B Nichols; J Andrew Alspaugh; James B Gloer; Gerald F Bills
Journal:  J Ind Microbiol Biotechnol       Date:  2021-12-23       Impact factor: 4.258
  7 in total

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