Renan B Domingues1,2, Halina Duarte1, Carlos Senne2,3, Gustavo Bruniera2,3, Fernando Brunale2,3, Natália P Rocha4, Antonio L Teixeira1,4. 1. Universidade Federal de Minas Gerais, Programa de Neurociências, Belo Horizonte MG, Brasil; 2. Senne Liquor Diagnóstico, São Paulo SP, Brasil; 3. Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil; 4. Hospital Israelita Albert Einstein, Laboratório de Patologia Clínica, São Paulo SP, Brasil.
Abstract
OBJECTIVES: Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. METHODS: This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. RESULTS: We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. CONCLUSIONS: This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.
OBJECTIVES: Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. METHODS: This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. RESULTS: We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. CONCLUSIONS: This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.
Authors: Marisa Flook; Lidia Frejo; Alvaro Gallego-Martinez; Eduardo Martin-Sanz; Marcos Rossi-Izquierdo; Juan Carlos Amor-Dorado; Andres Soto-Varela; Sofia Santos-Perez; Angel Batuecas-Caletrio; Juan Manuel Espinosa-Sanchez; Patricia Pérez-Carpena; Marta Martinez-Martinez; Ismael Aran; Jose Antonio Lopez-Escamez Journal: Front Immunol Date: 2019-06-04 Impact factor: 7.561