Literature DB >> 27555505

Blood Pressure, Sexual Activity, and Dysfunction in Women With Hypertension: Baseline Findings From the Systolic Blood Pressure Intervention Trial (SPRINT).

Capri G Foy1, Jill C Newman2, Dan R Berlowitz3, Laurie P Russell2, Paul L Kimmel4, Virginia G Wadley5, Holly N Thomas6, Alan J Lerner7, William T Riley8.   

Abstract

INTRODUCTION: Sexual function, an important component of quality of life, is gaining increased research and clinical attention in older women with hypertension. AIM: To assess the association between systolic blood pressure (SBP) and other variables, and sexual activity and sexual dysfunction in hypertensive women.
METHODS: Baseline analysis of 635 women participants of a larger randomized clinical trial of 9361 men and women. MAIN OUTCOME MEASURES: Self-reported sexual activity (yes/no), and sexual function using the Female Sexual Function Inventory (FSFI).
RESULTS: 452 participants (71.2%) reported having no sexual activity during the previous 4 weeks. The mean (SD) FSFI score for sexually active participants was 25.3 (6.0), and 52.6% of the sample reported a FSFI score ≤26.55 designating sexual dysfunction. In logistic regression models, SBP was not significantly associated with sexual activity (AOR = 1.002; P > .05). Older age (AOR = 0.95, P < .05), and lower education (AOR for < high school vs college degree = 0.29, P < .05) were associated with lower odds of being sexually active, as was living alone versus living with others (AOR = 0.56, P < .05). Higher weekly alcohol consumption was associated with increased odds of being sexually active (AOR = 1.39; P < .05). In logistic regression models among sexually active participants, SBP was not associated with sexual dysfunction (AOR = 1.01; P > .05). Higher depressive symptoms from the Patient Health Questionnaire-9 (PHQ-9) was associated with higher odds of sexual dysfunction (AOR = 1.24, P < .05), as was increased number of physical comorbidities (AOR = 1.25, P < .05). Diuretic use was associated with lower odds of being sexually active in participants with chronic kidney disease (AOR = 0.33, P < .05).
CONCLUSION: Younger age, higher education, living with others, and higher weekly alcohol consumption were significantly associated with higher odds of being sexually active in a sample of middle-aged and older women with hypertension. Increased depressive symptoms and increased physical comorbidities were significantly associated with increased odds of sexual dysfunction. SBP was not significantly associated with sexual activity or sexual dysfunction.
Copyright © 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Antihypertensive Medications; Blood Pressure; Older Women; Sexual Activity; Sexual Function

Mesh:

Year:  2016        PMID: 27555505      PMCID: PMC5030072          DOI: 10.1016/j.jsxm.2016.06.014

Source DB:  PubMed          Journal:  J Sex Med        ISSN: 1743-6095            Impact factor:   3.802


  43 in total

Review 1.  The making of a disease: female sexual dysfunction.

Authors:  Ray Moynihan
Journal:  BMJ       Date:  2003-01-04

2.  The PHQ-9: validity of a brief depression severity measure.

Authors:  K Kroenke; R L Spitzer; J B Williams
Journal:  J Gen Intern Med       Date:  2001-09       Impact factor: 5.128

3.  Effect of antihypertensives on sexual function and quality of life: the TAIM Study.

Authors:  S Wassertheil-Smoller; M D Blaufox; A Oberman; B R Davis; C Swencionis; M O Knerr; C M Hawkins; H G Langford
Journal:  Ann Intern Med       Date:  1991-04-15       Impact factor: 25.391

Review 4.  Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysis.

Authors:  Evan Atlantis; Thomas Sullivan
Journal:  J Sex Med       Date:  2012-03-29       Impact factor: 3.802

5.  Does hypertension and its pharmacotherapy affect the quality of sexual function in women?

Authors:  L E Duncan; C Lewis; P Jenkins; T A Pearson
Journal:  Am J Hypertens       Date:  2000-06       Impact factor: 2.689

6.  Sexual dysfunction in women with ESRD requiring hemodialysis.

Authors:  Giovanni F M Strippoli; Mariacristina Vecchio; Suetonia Palmer; Giorgia De Berardis; Jonathan Craig; Giuseppe Lucisano; David Johnson; Fabio Pellegrini; Antonio Nicolucci; Michela Sciancalepore; Valeria Saglimbene; Letizia Gargano; Carmen Bonifati; Marinella Ruospo; Sankar D Navaneethan; Vincenzo Montinaro; Paul Stroumza; Marianna Zsom; Mariatta Torok; Eduardo Celia; Ruben Gelfman; Anna Bednarek-Skublewska; Jan Dulawa; Giusi Graziano; Giorgio Gentile; Juan Nin Ferrari; Antonio Santoro; Annalisa Zucchelli; Giorgio Triolo; Stefano Maffei; Jörgen Hegbrant; Charlotta Wollheim; Salvatore De Cosmo; Valeria M Manfreda
Journal:  Clin J Am Soc Nephrol       Date:  2012-04-05       Impact factor: 8.237

7.  Sexual dysfunction in the United States: prevalence and predictors.

Authors:  E O Laumann; A Paik; R C Rosen
Journal:  JAMA       Date:  1999-02-10       Impact factor: 56.272

8.  Comorbidity assessments based on patient report: results from the Veterans Health Study.

Authors:  Alfredo J Selim; Graeme Fincke; Xinhua S Ren; Austin Lee; William H Rogers; Donald R Miller; Katherine M Skinner; Mark Linzer; Lewis E Kazis
Journal:  J Ambul Care Manage       Date:  2004 Jul-Sep

9.  The association of physical and mental health with sexual activity in older adults in a retirement community.

Authors:  Lynea E Bach; James A Mortimer; Carla VandeWeerd; Jaime Corvin
Journal:  J Sex Med       Date:  2013-08-23       Impact factor: 3.802

10.  Effect of valsartan and atenolol on sexual behavior in hypertensive postmenopausal women.

Authors:  Roberto Fogari; Paola Preti; Annalisa Zoppi; Luca Corradi; Carlo Pasotti; Andrea Rinaldi; Amedeo Mugellini
Journal:  Am J Hypertens       Date:  2004-01       Impact factor: 2.689

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  4 in total

1.  Sexualıty and marıtal adjustment ın women wıth hypertensıon ın Turkey: how culture affects sex.

Authors:  Ozlem Ceyhan; Betul Ozen; Nuray Simsek; Aydan Dogan
Journal:  J Hum Hypertens       Date:  2019-02-25       Impact factor: 3.012

Review 2.  Female Sexual Function at Midlife and Beyond.

Authors:  Holly N Thomas; Genevieve S Neal-Perry; Rachel Hess
Journal:  Obstet Gynecol Clin North Am       Date:  2018-10-25       Impact factor: 2.844

Review 3.  The Impact of Metabolic Syndrome and Its Components on Female Sexual Dysfunction: A Narrative Mini-Review.

Authors:  Simona Di Francesco; Marika Caruso; Iole Robuffo; Andrea Militello; Elena Toniato
Journal:  Curr Urol       Date:  2019-03-08

Review 4.  "Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial".

Authors:  Van T Hoang; Hoang-Phuong Nguyen; Viet Nhan Nguyen; Duc M Hoang; Tan-Sinh Thi Nguyen; Liem Nguyen Thanh
Journal:  Front Cell Dev Biol       Date:  2022-09-28
  4 in total

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