Literature DB >> 27555347

NRF2: Translating the Redox Code.

Krishna S Tummala1, Filippos Kottakis1, Nabeel Bardeesy2.   

Abstract

Cancer requires mechanisms to mitigate reactive oxygen species (ROS) generated during rapid growth, such as induction of the antioxidant transcription factor, Nrf2. However, the targets of ROS-mediated cytotoxicity are unclear. Recent studies in pancreatic cancer show that redox control by Nrf2 prevents cysteine oxidation of the mRNA translational machinery, thereby supporting efficient protein synthesis.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27555347      PMCID： PMC5131791          DOI： 10.1016/j.molmed.2016.08.002

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  9 in total

Review 1.  Cellular mechanisms and physiological consequences of redox-dependent signalling.

Authors:  Kira M Holmström; Toren Finkel
Journal:  Nat Rev Mol Cell Biol       Date:  2014-06       Impact factor: 94.444

2.  NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

Authors:  Iok In Christine Chio; Seyed Mehdi Jafarnejad; Mariano Ponz-Sarvise; Youngkyu Park; Keith Rivera; Wilhelm Palm; John Wilson; Vineet Sangar; Yuan Hao; Daniel Öhlund; Kevin Wright; Dea Filippini; Eun Jung Lee; Brandon Da Silva; Christina Schoepfer; John Erby Wilkinson; Jonathan M Buscaglia; Gina M DeNicola; Herve Tiriac; Molly Hammell; Howard C Crawford; Edward E Schmidt; Craig B Thompson; Darryl J Pappin; Nahum Sonenberg; David A Tuveson
Journal:  Cell       Date:  2016-07-28       Impact factor: 41.582

Review 3.  ROS-dependent signal transduction.

Authors:  Colleen R Reczek; Navdeep S Chandel
Journal:  Curr Opin Cell Biol       Date:  2014-10-08       Impact factor: 8.382

4.  Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

Authors:  Gina M DeNicola; Florian A Karreth; Timothy J Humpton; Aarthi Gopinathan; Cong Wei; Kristopher Frese; Dipti Mangal; Kenneth H Yu; Charles J Yeo; Eric S Calhoun; Francesca Scrimieri; Jordan M Winter; Ralph H Hruban; Christine Iacobuzio-Donahue; Scott E Kern; Ian A Blair; David A Tuveson
Journal:  Nature       Date:  2011-07-06       Impact factor: 49.962

Review 5.  The emerging role of the Nrf2-Keap1 signaling pathway in cancer.

Authors:  Melba C Jaramillo; Donna D Zhang
Journal:  Genes Dev       Date:  2013-10-15       Impact factor: 11.361

6.  NRF2 regulates serine biosynthesis in non-small cell lung cancer.

Authors:  Gina M DeNicola; Pei-Hsuan Chen; Edouard Mullarky; Jessica A Sudderth; Zeping Hu; David Wu; Hao Tang; Yang Xie; John M Asara; Kenneth E Huffman; Ignacio I Wistuba; John D Minna; Ralph J DeBerardinis; Lewis C Cantley
Journal:  Nat Genet       Date:  2015-10-19       Impact factor: 38.330

7.  Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Authors:  Jaekyoung Son; Costas A Lyssiotis; Haoqiang Ying; Xiaoxu Wang; Sujun Hua; Matteo Ligorio; Rushika M Perera; Cristina R Ferrone; Edouard Mullarky; Ng Shyh-Chang; Ya'an Kang; Jason B Fleming; Nabeel Bardeesy; John M Asara; Marcia C Haigis; Ronald A DePinho; Lewis C Cantley; Alec C Kimmelman
Journal:  Nature       Date:  2013-03-27       Impact factor: 49.962

8.  Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.

Authors:  Caroline A Lewis; Seth J Parker; Brian P Fiske; Douglas McCloskey; Dan Y Gui; Courtney R Green; Natalie I Vokes; Adam M Feist; Matthew G Vander Heiden; Christian M Metallo
Journal:  Mol Cell       Date:  2014-05-29       Impact factor: 19.328

9.  Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities.

Authors:  Emma M Kerr; Edoardo Gaude; Frances K Turrell; Christian Frezza; Carla P Martins
Journal:  Nature       Date:  2016-02-24       Impact factor: 49.962
  9 in total
  4 in total

1.  Neuroprotective effect of L-deprenyl on the expression level of the Mst1 gene and inhibition of apoptosis in rat-model spinal cord injury.

Authors:  Alireza Abdanipour; Ali Nikfar; Mahsa Nikbakht Rad; Iraj Jafari Anarkooli; Mojdeh Mansouri
Journal:  Iran J Basic Med Sci       Date:  2022-01       Impact factor: 2.532

2.  Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation.

Authors:  Siliang Wang; Yuan-Yuan Wu; Xu Wang; Peiliang Shen; Qi Jia; Suyun Yu; Yuan Wang; Xiaoman Li; Wenxing Chen; Aiyun Wang; Yin Lu
Journal:  Aging (Albany NY)       Date:  2020-05-04       Impact factor: 5.682

3.  VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet-Induced Stress.

Authors:  Daisuke Sakano; Fumiya Uefune; Hiraku Tokuma; Yuki Sonoda; Kumi Matsuura; Naoki Takeda; Naomi Nakagata; Kazuhiko Kume; Nobuaki Shiraki; Shoen Kume
Journal:  Diabetes       Date:  2020-08-21       Impact factor: 9.461

4.  Valproic Acid Ameliorates Locomotor Function in the Rat Model of Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene Expression.

Authors:  Ali Mardi; Alireza Biglar; Reza Nejatbakhsh; Alireza Abdanipour
Journal:  Iran Biomed J       Date:  2021-07-01
  4 in total

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