Koji Ishii1, Tetsuji Makita2, Hikoma Yamashita3, Shoji Matsunaga3, Daiji Akiyama3, Kouko Toba3, Katsumi Hara3, Koji Sumikawa4, Tetsuya Hara2. 1. Department of Anesthesia, Sasebo City General Hospital, Sasebo, Japan; Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan. Electronic address: soukenbicha141kouji@yahoo.co.jp. 2. Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan. 3. Department of Anesthesia, Sasebo City General Hospital, Sasebo, Japan. 4. Department of Anesthesia, Saiseikai Nagasaki Hospital, Nagasaki, Japan.
Abstract
STUDY OBJECTIVE:Postoperative delirium (POD) is a common complication of anesthesia. The incidence of POD in elderly patients ranges from 37% to 53%, and POD increases the morbidity and mortality of elderly patients. However, the effects of anesthetics on POD are not well known. The present study aimed to compare the incidence of POD resulting from propofol and sevoflurane anesthesia. DESIGN: Double-blind prospective study. SETTING: Operating room and postoperative recovery area. PATIENTS: Thirty patients in the sevoflurane anesthesia group and 29 in the propofol anesthesia group. MEASUREMENTS: Statistical analyses were performed using Microsoft Excel 2010 for Windows 7 (Microsoft Corporation, Redmond, Wash). Statistical analysis was performed using Fisher exact test and Student t test. MAIN RESULTS: The incidence of POD in the propofol anesthesia (6.9%) was significantly less than that observed in the sevoflurane anesthesia (26.7%; 038). CONCLUSION: In comparison with sevoflurane anesthesia, propofol anesthesia is associated with a lower incidence of POD in elderly patients.
RCT Entities:
STUDY OBJECTIVE:Postoperative delirium (POD) is a common complication of anesthesia. The incidence of POD in elderly patients ranges from 37% to 53%, and POD increases the morbidity and mortality of elderly patients. However, the effects of anesthetics on POD are not well known. The present study aimed to compare the incidence of POD resulting from propofol and sevoflurane anesthesia. DESIGN: Double-blind prospective study. SETTING: Operating room and postoperative recovery area. PATIENTS: Thirty patients in the sevoflurane anesthesia group and 29 in the propofol anesthesia group. MEASUREMENTS: Statistical analyses were performed using Microsoft Excel 2010 for Windows 7 (Microsoft Corporation, Redmond, Wash). Statistical analysis was performed using Fisher exact test and Student t test. MAIN RESULTS: The incidence of POD in the propofol anesthesia (6.9%) was significantly less than that observed in the sevoflurane anesthesia (26.7%; 038). CONCLUSION: In comparison with sevoflurane anesthesia, propofol anesthesia is associated with a lower incidence of POD in elderly patients.
Authors: David Miller; Sharon R Lewis; Michael W Pritchard; Oliver J Schofield-Robinson; Cliff L Shelton; Phil Alderson; Andrew F Smith Journal: Cochrane Database Syst Rev Date: 2018-08-21
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