Literature DB >> 27554985

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles.

Yan Li1, Ying Lei Wong1, Michelle Yueqi Lee1, Qingxin Li2, Qing-Yin Wang3, Julien Lescar4, Pei-Yong Shi5, CongBao Kang6.   

Abstract

Dengue virus nonstructural protein 4B (NS4B) is a membrane protein consisting of 248 residues with a crucial role in virus replication and interference with the host innate immunity. The dengue virus serotype 3 NS4B was reconstituted into lyso-myristoyl phosphatidylglycerol (LMPG) micelles. Backbone resonance assignment of NS4B was obtained using conventional solution NMR experiments. Further studies suggested that NS4B contained eleven helices and six of them form five potential transmembrane regions. This study provides atomic level information for an important drug target to control flavivirus infections.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  NMR spectroscopy; NS4B; dengue virus; membrane protein; membrane topology

Mesh：

Substances：

Year:  2016        PMID： 27554985     DOI： 10.1002/anie.201606609

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  9 in total

Review 1.  Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins.

Authors:  Qingxin Li; Congbao Kang
Journal:  Membranes (Basel)       Date:  2022-02-17

Review 2.  Solution NMR Spectroscopy in Target-Based Drug Discovery.

Authors:  Yan Li; Congbao Kang
Journal:  Molecules       Date:  2017-08-23       Impact factor: 4.411

3.  Dengue virus nonstructural 3 protein interacts directly with human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and reduces its glycolytic activity.

Authors:  Emiliana M Silva; Jonas N Conde; Diego Allonso; Gustavo T Ventura; Diego R Coelho; Pedro Henrique Carneiro; Manuela L Silva; Marciano V Paes; Kíssila Rabelo; Gilberto Weissmuller; Paulo Mascarello Bisch; Ronaldo Mohana-Borges
Journal:  Sci Rep       Date:  2019-02-25       Impact factor: 4.379

Review 4.  Compartmentalized replication organelle of flavivirus at the ER and the factors involved.

Authors:  Yali Ci; Lei Shi
Journal:  Cell Mol Life Sci       Date:  2021-04-12       Impact factor: 9.261

5.  In Silico Analysis of Dengue Virus Serotype 2 Mutations Detected at the Intrahost Level in Patients with Different Clinical Outcomes.

Authors:  Maria Celeste Torres; Ana Luiza Martins Karl; Matheus Müller Pereira da Silva; Laurent Emmanuel Dardenne; Ana Maria Bispo de Filippis
Journal:  Microbiol Spectr       Date:  2021-09-01

6.  Secondary Structures of the Transmembrane Domain of SARS-CoV-2 Spike Protein in Detergent Micelles.

Authors:  Qingxin Li; Qiwei Huang; Congbao Kang
Journal:  Int J Mol Sci       Date:  2022-01-18       Impact factor: 5.923

Review 7.  Let's Get Physical: Flavivirus-Host Protein-Protein Interactions in Replication and Pathogenesis.

Authors:  Adam T Fishburn; Oanh H Pham; Matthew W Kenaston; Nitin S Beesabathuni; Priya S Shah
Journal:  Front Microbiol       Date:  2022-03-03       Impact factor: 5.640

Review 8.  Dengue virus NS4B protein as a target for developing antivirals.

Authors:  Qingxin Li; Congbao Kang
Journal:  Front Cell Infect Microbiol       Date:  2022-08-09       Impact factor: 6.073

Review 9.  Molecular Insights into the Flavivirus Replication Complex.

Authors:  Kaïn van den Elsen; Jun Ping Quek; Dahai Luo
Journal:  Viruses       Date:  2021-05-21       Impact factor: 5.048
  9 in total

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