Literature DB >> 27554682

Semaphorins 4A and 4D in chronic inflammatory diseases.

Svetlana P Chapoval1,2, Zahava Vadasz3, Andrei I Chapoval4,5, Elias Toubi3.   

Abstract

Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.

Entities:  

Keywords:  Asthma; Autoimmune diseases; Cancer; Chronic inflammation; Semaphorins

Mesh：

Substances：

Year:  2016        PMID： 27554682     DOI： 10.1007/s00011-016-0983-5

Source DB:  PubMed          Journal:  Inflamm Res        ISSN： 1023-3830            Impact factor:   4.575


  41 in total

1.  The Involvement of Immune Semaphorins in the Pathogenesis of Inflammatory Bowel Diseases (IBDs).

Authors:  Zahava Vadasz; Tova Rainis; Afif Nakhleh; Tharwat Haj; Jacob Bejar; Katty Halasz; Elias Toubi
Journal:  PLoS One       Date:  2015-05-15       Impact factor: 3.240

2.  Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.

Authors:  John R Basile; Talayeh Afkhami; J Silvio Gutkind
Journal:  Mol Cell Biol       Date:  2005-08       Impact factor: 4.272

Review 3.  The Plexin-B family and its role in cancer progression.

Authors:  Muhammad Faraz Arshad Malik; Lin Ye; Wen G Jiang
Journal:  Histol Histopathol       Date:  2013-09-17       Impact factor: 2.303

4.  An inhibitory role for Sema4A in antigen-specific allergic asthma.

Authors:  Tetsuo Morihana; Sho Goya; Masayuki Mizui; Teruhito Yasui; Durubaka V R Prasad; Atsushi Kumanogoh; Manabu Tamura; Takashi Shikina; Yohei Maeda; Yoriko Iwamoto; Hidenori Inohara; Hitoshi Kikutani
Journal:  J Clin Immunol       Date:  2012-09-25       Impact factor: 8.317

5.  Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis.

Authors:  Li Zhu; Timothy J Stalker; Karen P Fong; Hong Jiang; Anh Tran; Irene Crichton; Eric K Lee; Keith B Neeves; Sean F Maloney; Hitoshi Kikutani; Atsushi Kumanogoh; Ellen Pure; Scott L Diamond; Lawrence F Brass
Journal:  Arterioscler Thromb Vasc Biol       Date:  2009-04-23       Impact factor: 8.311

6.  Involvement of Sema4A in the progression of experimental autoimmune myocarditis.

Authors:  Nobuhiko Makino; Toshihiko Toyofuku; Noriko Takegahara; Hyota Takamatsu; Tatsusada Okuno; Yukinobu Nakagawa; Sujin Kang; Satoshi Nojima; Masatsugu Hori; Hitoshi Kikutani; Atsushi Kumanogoh
Journal:  FEBS Lett       Date:  2008-10-31       Impact factor: 4.124

7.  Sema4D induces angiogenesis through Met recruitment by Plexin B1.

Authors:  Paolo Conrotto; Donatella Valdembri; Simona Corso; Guido Serini; Luca Tamagnone; Paolo Maria Comoglio; Federico Bussolino; Silvia Giordano
Journal:  Blood       Date:  2005-01-04       Impact factor: 22.113

8.  Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition.

Authors:  Milka Sarris; Kristian G Andersen; Felix Randow; Luzia Mayr; Alexander G Betz
Journal:  Immunity       Date:  2008-03-06       Impact factor: 31.745

9.  Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

Authors:  Greg M Delgoffe; Seng-Ryong Woo; Meghan E Turnis; David M Gravano; Cliff Guy; Abigail E Overacre; Matthew L Bettini; Peter Vogel; David Finkelstein; Jody Bonnevier; Creg J Workman; Dario A A Vignali
Journal:  Nature       Date:  2013-08-04       Impact factor: 49.962

10.  Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.

Authors:  Eduard Schulz; Petra Klampfl; Stefanie Holzapfel; Andreas R Janecke; Peter Ulz; Wilfried Renner; Karl Kashofer; Satoshi Nojima; Anita Leitner; Armin Zebisch; Albert Wölfler; Sybille Hofer; Armin Gerger; Sigurd Lax; Christine Beham-Schmid; Verena Steinke; Ellen Heitzer; Jochen B Geigl; Christian Windpassinger; Gerald Hoefler; Michael R Speicher; C Richard Boland; Atsushi Kumanogoh; Heinz Sill
Journal:  Nat Commun       Date:  2014-10-13       Impact factor: 14.919
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  14 in total

1.  Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1.

Authors:  Svetlana P Chapoval; Molly Hritzo; Xiulan Qi; Luca Tamagnone; Amit Golding; Achsah D Keegan
Journal:  Immunohorizons       Date:  2019-02

Review 2.  Neuroimmune semaphorins as costimulatory molecules and beyond.

Authors:  Svetlana P Chapoval
Journal:  Mol Med       Date:  2018-04-04       Impact factor: 6.354

3.  Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis.

Authors:  Brian Chiou; Elisabeth Lucassen; Michael Sather; Asha Kallianpur; James Connor
Journal:  Glia       Date:  2018-02-19       Impact factor: 7.452

4.  Insufficient CD100 shedding contributes to suppression of CD8+ T-cell activity in non-small cell lung cancer.

Authors:  Hong-Min Wang; Xiao-Hong Zhang; Li-Qun Ye; Kai Zhang; Ning-Ning Yang; Shen Geng; Jing Chen; Shun-Xin Zhao; Kang-Li Yang; Fei-Fei Fan
Journal:  Immunology       Date:  2020-04-07       Impact factor: 7.397

Review 5.  Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy.

Authors:  David H Munn; Madhav D Sharma; Theodore S Johnson
Journal:  Cancer Res       Date:  2018-09-04       Impact factor: 12.701

Review 6.  Semaphorins and Their Receptors: From Axonal Guidance to Atherosclerosis.

Authors:  Shuhong Hu; Li Zhu
Journal:  Front Physiol       Date:  2018-10-12       Impact factor: 4.566

Review 7.  CD100 Effects in Macrophages and Its Roles in Atherosclerosis.

Authors:  Maria C A Luque; Mariana K Galuppo; Janaina Capelli-Peixoto; Beatriz S Stolf
Journal:  Front Cardiovasc Med       Date:  2018-09-28

8.  Sja-miR-71a in Schistosome egg-derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D.

Authors:  Lifu Wang; Yao Liao; Ruibing Yang; Zilong Yu; Lichao Zhang; Zifeng Zhu; Xiaoying Wu; Jia Shen; Jiahua Liu; Lian Xu; Zhongdao Wu; Xi Sun
Journal:  J Extracell Vesicles       Date:  2020-07-09

9.  Neutrophil-Derived Semaphorin 4D Induces Inflammatory Cytokine Production of Endothelial Cells via Different Plexin Receptors in Kawasaki Disease.

Authors:  Junhua Huang; Shouzhen Wu; Sancheng Cao; Xieying Zhu; Shuwan Zhang
Journal:  Biomed Res Int       Date:  2020-12-16       Impact factor: 3.411

10.  Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome.

Authors:  Feeling YuTing Chen; Eliza Gaylord; Nancy McNamara; Sarah Knox
Journal:  Int J Mol Sci       Date:  2018-11-17       Impact factor: 5.923
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