Sebastian Rasch1, Irena Valantiene2, Artautas Mickevicius3, Sebastian Beer4, Jonas Rosendahl5, Richard M Charnley6, Stuart M Robinson6. 1. II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Germany. Electronic address: sebastian.rasch@mri.tum.de. 2. Department of Gastroenterology LUHSH Kauno klinikos, Kaunas, Lithuania. 3. Centre of Hepatology, Gastroenterology and Dietetics, Vilnius University Hospital SANTARIŠKIŲ KLINIKOS, Vilnius, Lithuania. 4. Department for Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany. 5. Department of Gastroenterology and Hepatology, University of Halle, Halle, Germany. 6. HPB Unit, Department of Surgery, Freeman Hospital, Newcastle upon Tyne, UK.
Abstract
BACKGROUND: Chronic pancreatitis is an inflammatory disorder of the pancreas that is associated with accelerated mortality for patients suffering from this disease. The association between chronic inflammation and accelerated biological ageing has been well described and is often referred to as "inflammageing". In this review we seek to determine how systemic inflammation in chronic pancreatitis may contribute to an accelerated ageing phenotype. METHODS: A systematic literature search with a predefined search protocol was performed on Medline, Embase and Cochrane libraries according to the PRISMA guidelines. RESULTS: The initial search identified 499 studies. After title, abstract and full text screen of the search results, 20 were included for further evaluation. In the 20 remaining articles 41 inflammatory mediators were identified - mainly involved in chronic inflammation, fibrosis and particularly cardinal features of inflammageing such as sarcopenia and osteoporosis. CONCLUSION: Chronic pancreatitis is associated with elevated levels of inflammatory mediators many of which are associated with an accelerated ageing phenotype and may explain some of the clinical sequelae of this disease.
BACKGROUND:Chronic pancreatitis is an inflammatory disorder of the pancreas that is associated with accelerated mortality for patients suffering from this disease. The association between chronic inflammation and accelerated biological ageing has been well described and is often referred to as "inflammageing". In this review we seek to determine how systemic inflammation in chronic pancreatitis may contribute to an accelerated ageing phenotype. METHODS: A systematic literature search with a predefined search protocol was performed on Medline, Embase and Cochrane libraries according to the PRISMA guidelines. RESULTS: The initial search identified 499 studies. After title, abstract and full text screen of the search results, 20 were included for further evaluation. In the 20 remaining articles 41 inflammatory mediators were identified - mainly involved in chronic inflammation, fibrosis and particularly cardinal features of inflammageing such as sarcopenia and osteoporosis. CONCLUSION:Chronic pancreatitis is associated with elevated levels of inflammatory mediators many of which are associated with an accelerated ageing phenotype and may explain some of the clinical sequelae of this disease.
Authors: Walter G Park; Liang Li; Savitri Appana; Wei Wei; Kimberly Stello; Dana K Andersen; Steven J Hughes; David C Whitcomb; Randall E Brand; Dhiraj Yadav; Aida Habtezion Journal: Pancreatology Date: 2019-11-25 Impact factor: 3.996
Authors: Julia B Greer; Phil Greer; Bimaljit S Sandhu; Samer Alkaade; C Mel Wilcox; Michelle A Anderson; Stuart Sherman; Timothy B Gardner; Michele D Lewis; Nalini M Guda; Thiruvengadam Muniraj; Darwin Conwell; Gregory A Cote; Christopher E Forsmark; Peter A Banks; Gong Tang; Kim Stello; Andres Gelrud; Randall E Brand; Adam Slivka; David C Whitcomb; Dhiraj Yadav Journal: Nutr Clin Pract Date: 2018-08-13 Impact factor: 3.080
Authors: Sebastian Rasch; Bärbel Nötzel; Veit Phillip; Tobias Lahmer; Roland M Schmid; Hana Algül Journal: PLoS One Date: 2017-09-06 Impact factor: 3.240
Authors: Stuart M Robinson; Sebastian Rasch; Sebastian Beer; Irena Valantiene; Artautas Mickevicius; Elisabeth Schlaipfer; Jelena Mann; Patrick Maisonneuve; Richard M Charnley; Jonas Rosendahl Journal: Sci Rep Date: 2019-05-13 Impact factor: 4.379