Literature DB >> 2755456

The effect of adenine nucleotides on the rate and fate of glutamine utilization by incubated mitochondria isolated from rat mesenteric lymph nodes.

R Curi1, E A Newsholme.   

Abstract

The rate of glutamine utilization by isolated lymphocyte mitochondria is 21.4 nmol/min per mg protein, of which 72% is converted to glutamate. Addition of ATP, ADP or AMP increased the rate of glutamine utilization by 60%. Evidence is presented that this is due to a stimulation of oxoglutarate dehydrogenase activity by ADP: this may account for the stimulation of glutamine utilization by concanavalin A in lymphocyte.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2755456     DOI： 10.1007/BF00231691

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  11 in total

1.  THE DEPENDENCE OF CONTRACTION AND RELAXATION OF MUSCLE FIBRES FROM THE CRAB MAIA SQUINADO ON THE INTERNAL CONCENTRATION OF FREE CALCIUM IONS.

Authors:  H PORTZEHL; P C CALDWELL; J C RUEEGG
Journal:  Biochim Biophys Acta       Date:  1964-05-25

2.  Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues.

Authors:  R M Denton; D A Richards; J G Chin
Journal:  Biochem J       Date:  1978-12-15       Impact factor: 3.857

3.  Intracellular distribution of some enzymes of the glutamine utilisation pathway in rat lymphocytes.

Authors:  R Curi; P Newsholme; E A Newsholme
Journal:  Biochem Biophys Res Commun       Date:  1986-07-16       Impact factor: 3.575

4.  P 1 ,P 5 -Di(adenosine-5')pentaphosphate, a potent multisubstrate inhibitor of adenylate kinase.

Authors:  G E Lienhard; I I Secemski
Journal:  J Biol Chem       Date:  1973-02-10       Impact factor: 5.157

Review 5.  Metabolism in lymphocytes and its importance in the immune response.

Authors:  M S Ardawi; E A Newsholme
Journal:  Essays Biochem       Date:  1985       Impact factor: 8.000

6.  Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+.

Authors:  J G McCormack; R M Denton
Journal:  Biochem J       Date:  1984-02-15       Impact factor: 3.857

7.  Maximum activities of some enzymes of glycolysis, the tricarboxylic acid cycle and ketone-body and glutamine utilization pathways in lymphocytes of the rat.

Authors:  M S Ardawi; E A Newsholme
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857

8.  Glutamine metabolism in lymphocytes of the rat.

Authors:  M S Ardawi; E A Newsholme
Journal:  Biochem J       Date:  1983-06-15       Impact factor: 3.857

9.  The effect of prostaglandins E1, E2 and F2 alpha and indomethacin on the sensitivity of glycolysis and glycogen synthesis to insulin in stripped soleus muscles of the rat.

Authors:  B Leighton; L Budohoski; F J Lozeman; R A Challiss; E A Newsholme
Journal:  Biochem J       Date:  1985-04-01       Impact factor: 3.857

10.  Metabolism of pyruvate by isolated rat mesenteric lymphocytes, lymphocyte mitochondria and isolated mouse macrophages.

Authors:  R Curi; P Newsholme; E A Newsholme
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.