Sharma Kattel1, Takatoshi Kasai2, Hiroki Matsumoto3, Shoichiro Yatsu1, Azusa Murata1, Takao Kato1, Shoko Suda3, Masaru Hiki1, Atsutoshi Takagi1, Hiroyuki Daida1. 1. Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan. 2. Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan; Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: kasai-t@mx6.nisiq.net. 3. Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan; Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Abstract
BACKGROUND: The effect of elevated blood glucose (BG) levels on the long-term prognosis of acute decompensated heart failure (ADHF) patients has not been well defined. The purpose of this study is to evaluate the long-term prognosis of ADHF with elevated BG. METHODS: A cohort of patients consecutively admitted to the cardiac intensive care unit from 2007 to 2011 was studied. Among these, 495 patients who met the criteria were divided into 4 groups based on their BG level and diabetes mellitus (DM) status. The risks for all-cause mortality in each group were assessed using the multivariate Cox proportional hazards model. RESULTS: At a median follow-up of 1.8 years, 148 patients had died. There were 168 patients without either BG elevation or DM, 67 without BG elevation but with DM, 105 with BG elevation but not DM, and 155 with both BG elevation and DM. In a multivariate model, those with BG elevation, regardless of DM status, showed a greater risk of increased mortality when compared with patients without either BG elevation or DM [hazard ratio (HR), 1.79; p=0.042 for BG elevation without DM and HR, 1.73; p=0.048 for BG elevation with DM]. CONCLUSION: Elevated BG levels, irrespective of the DM status, at the time of admission in patients with ADHF, appear to be a prognostic marker for ADHF.
BACKGROUND: The effect of elevated blood glucose (BG) levels on the long-term prognosis of acute decompensated heart failure (ADHF) patients has not been well defined. The purpose of this study is to evaluate the long-term prognosis of ADHF with elevated BG. METHODS: A cohort of patients consecutively admitted to the cardiac intensive care unit from 2007 to 2011 was studied. Among these, 495 patients who met the criteria were divided into 4 groups based on their BG level and diabetes mellitus (DM) status. The risks for all-cause mortality in each group were assessed using the multivariate Cox proportional hazards model. RESULTS: At a median follow-up of 1.8 years, 148 patients had died. There were 168 patients without either BG elevation or DM, 67 without BG elevation but with DM, 105 with BG elevation but not DM, and 155 with both BG elevation and DM. In a multivariate model, those with BG elevation, regardless of DM status, showed a greater risk of increased mortality when compared with patients without either BG elevation or DM [hazard ratio (HR), 1.79; p=0.042 for BG elevation without DM and HR, 1.73; p=0.048 for BG elevation with DM]. CONCLUSION: Elevated BG levels, irrespective of the DM status, at the time of admission in patients with ADHF, appear to be a prognostic marker for ADHF.
Authors: Osnat Itzhaki Ben Zadok; Ran Kornowski; Ilan Goldenberg; Robert Klempfner; Yoel Toledano; Yitschak Biton; Enrique Z Fisman; Alexander Tenenbaum; Gregory Golovchiner; Ehud Kadmon; Alexander Omelchenko; Tuvia Ben Gal; Alon Barsheshet Journal: Cardiovasc Diabetol Date: 2017-08-14 Impact factor: 9.951
Authors: Sua Kim; Soo Jin Na; Taek Kyu Park; Joo Myung Lee; Young Bin Song; Jin-Oh Choi; Joo-Yong Hahn; Jin-Ho Choi; Seung-Hyuk Choi; Hyeon-Cheol Gwon; Chi Ryang Chung; Kyeongman Jeon; Gee Young Suh; Jeong Hoon Yang Journal: J Korean Med Sci Date: 2019-02-27 Impact factor: 2.153