Iman Hamed Elmaadawi1, Basma Mourad Mohamed1, Zeinab Abel Samad Ibrahim1, Said Mohamed Abdou2, Yasmina Ahmed El Attar1, Amira Youssef2, Maha Mostafa Shamloula3, Atef Taha4, Hala Gabr Metwally5, Mohamed M El Afandy6, Mohamed Labib Salem7. 1. a Department of Dematology and Venereology , Faculty of Medicine, Tanta University , Tanta , Egypt. 2. b Department of Clinical Pathology , Faculty of Medicine, Tanta University , Tanta , Egypt. 3. c Department of Pathology , Faculty of Medicine, Tanta University , Tanta , Egypt. 4. d Department of Internal Medicine, Faculty of Medicine , Tanta University , Tanta , Egypt. 5. e Department Clinical Pathology, Faculty of Medicine , Cairo University , Cairo , Egypt. 6. f Department of Anathesia and Intensive Care, Faculty of Medicine , Tanta University , Tanta , Egypt. 7. g Department of Zoology, Immunology and Biotechnology Unit, Faculty of Science , Center of Excellence in Cancer Research, Tanta University , Tanta , Egypt.
Abstract
BACKGROUND: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challenging as patients may be resistant to currently available modalities of treatment. The use of stem cells may be a novel option for resistant cases. OBJECTIVE: To evaluate the safety and efficacy of the use of autologous bone marrow derived mononuclear cells (including stem cells) as compared to follicular stems cells for the management of resistant cases of AA and AGA. METHODS: This study included 40 patients (20 AA patients and 20 AGA patients), all patients were treated with a single session of intradermal injection of autologous stem cells (SCs) therapy. They were divided into four groups according to the applied modality [either autologous bone marrow derived mononuclear cells (bone marrow mononuclear cells [BMMCs] or autologous follicular stem cells [FSC]). RESULTS: Six months after stem cell therapy (SCT) injection, there was a significant improvement, confirmed by immunostaining and digital dermoscopy. The mean improvement in all groups was "very good". There was no significant difference between both methods in either type of alopecia. No serious adverse events were reported. CONCLUSION: Autologous BMMCs and FSC seem to be a safe tolerable and effective treatment for the management of both resistant AA and AGA.
BACKGROUND: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challenging as patients may be resistant to currently available modalities of treatment. The use of stem cells may be a novel option for resistant cases. OBJECTIVE: To evaluate the safety and efficacy of the use of autologous bone marrow derived mononuclear cells (including stem cells) as compared to follicular stems cells for the management of resistant cases of AA and AGA. METHODS: This study included 40 patients (20 AA patients and 20 AGA patients), all patients were treated with a single session of intradermal injection of autologous stem cells (SCs) therapy. They were divided into four groups according to the applied modality [either autologous bone marrow derived mononuclear cells (bone marrow mononuclear cells [BMMCs] or autologous follicular stem cells [FSC]). RESULTS: Six months after stem cell therapy (SCT) injection, there was a significant improvement, confirmed by immunostaining and digital dermoscopy. The mean improvement in all groups was "very good". There was no significant difference between both methods in either type of alopecia. No serious adverse events were reported. CONCLUSION: Autologous BMMCs and FSC seem to be a safe tolerable and effective treatment for the management of both resistant AA and AGA.
Entities:
Keywords:
Bone marrow mononuclear cells; alopecia areata; androgenetic alopecia; digital dermoscopy-CK 15-CD34-CD200; follicular stem cells
Authors: B M Piraccini; U Blume-Peytavi; F Scarci; J M Jansat; M Falqués; R Otero; M L Tamarit; J Galván; V Tebbs; E Massana Journal: J Eur Acad Dermatol Venereol Date: 2021-10-25 Impact factor: 9.228