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Literature DB >> 27552920

The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair.

Divya Ramnath¹, Elizabeth E Powell², Glen M Scholz³, Matthew J Sweet⁴.

Abstract

In addition to their established roles in host defence, Toll-like Receptors (TLRs) have emerging roles in control of homeostasis, injury and wound repair. The dsRNA-sensing receptor, TLR3, has been particularly implicated in such processes in several different tissues including the skin, intestine and liver, as well as in the control of reparative mechanisms in the brain, heart and kidneys, following ischemia reperfusion injury. In this review, we provide an overview of TLR3 signalling and functions in inflammation, tissue damage and repair processes, as well as therapeutic opportunities that may arise in the future from knowledge of such pathways.

Entities: Disease Gene

Keywords: Homeostasis; Ischemia reperfusion injury; Poly(IC); Toll-like receptor 3; UV-damage; Wound repair

Mesh：

Substances：
Toll-Like Receptor 3

Year: 2016 PMID： 27552920 DOI： 10.1016/j.semcdb.2016.08.014

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

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Cited

9 in total

1. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice.

Authors: Tian Deng; Caixia Suo; Jiali Chang; Rui Yang; Jingyu Li; Ting Cai; Ju Qiu
Journal: Cell Mol Immunol Date: 2019-02-13 Impact factor: 11.530

Review 2. Cardiac Shockwave Therapy - A Novel Therapy for Ischemic Cardiomyopathy?

Authors: Michael Graber; Felix Nägele; Jakob Hirsch; Leo Pölzl; Victor Schweiger; Sophia Lechner; Michael Grimm; John P Cooke; Can Gollmann-Tepeköylü; Johannes Holfeld
Journal: Front Cardiovasc Med Date: 2022-05-12

3. Intestinal Epithelial Cells Express Immunomodulatory ISG15 During Active Ulcerative Colitis and Crohn's Disease.

Authors: Ann Elisabet Østvik; Tarjei Dahl Svendsen; Atle van Beelen Granlund; Berit Doseth; Helene Kolstad Skovdahl; Ingunn Bakke; Silje Thorsvik; Wahida Afroz; Gunnar Andreas Walaas; Tom Eirik Mollnes; Björn Inge Gustafsson; Arne Kristian Sandvik; Torunn Bruland
Journal: J Crohns Colitis Date: 2020-07-30 Impact factor: 9.071

4. CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

Authors: Lucas Fauquier; Karim Azzag; Marco Antonio Mendoza Parra; Aurélie Quillien; Manon Boulet; Sarah Diouf; Gilles Carnac; Lucas Waltzer; Hinrich Gronemeyer; Laurence Vandel
Journal: Sci Rep Date: 2018-08-22 Impact factor: 4.379

The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair.

1. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice.

Review 2. Cardiac Shockwave Therapy - A Novel Therapy for Ischemic Cardiomyopathy?

3. Intestinal Epithelial Cells Express Immunomodulatory ISG15 During Active Ulcerative Colitis and Crohn's Disease.

4. CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

5. Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA.

Review 6. Healing the Broken Heart; The Immunomodulatory Effects of Stem Cell Therapy.

7. dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing.

8. Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.

9. Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis.