Literature DB >> 27552901

Mechanism of action of herbs and their active constituents used in hair loss treatment.

Anna Herman1, Andrzej P Herman2.   

Abstract

This article discusses the mechanisms via topically applied products containing herbs and their active constituents affect the hair growth process. It was reported that the mechanisms involving (1) insulin-like growth factor-I (IGF-I), (2) vascular endothelial growth factor (VEGF), (3) epidermal growth factor (EGF), (4) fibroblast growth factor 2 (FGF-2), (5) endothelial nitric oxide synthase (eNOS), (6) Wnt/β-catenin signalling pathway, (7) prostaglandin E (PGE), (8) prostaglandin F (PGF) stimulate hair growth, whereas the mechanisms engaging (1) 5α-reductase and dihydrotestosterone (DHT), (2) transforming growth factor beta (TGF-β), (3) fibroblast growth factor 5 (FGF-5), (4) prostaglandin D2 (PGD2) inhibit hair growth. The knowledge summarized in the paper may be an inspiration to create new preparations for the treatment of hair loss.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Hair growth; Hair loss; Herbs; Herbs active constituents; Mechanism of action

Mesh：

Substances：

Year:  2016        PMID： 27552901     DOI： 10.1016/j.fitote.2016.08.008

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  14 in total

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9.  Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study.

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