Hong Pan1, Beili Chen, Jing Wang, Xi Wang, Ping Hu, Shinan Wu, Yunyun Liu, Zuying Xu, Wei Zhang, Binbin Wang, Yunxia Cao. 1. 1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China2National Research Institute for Family Planning, Beijing, China3College of Basic Medicine, Capital University of Medical Sciences, Beijing, China.
Abstract
OBJECTIVE: To determine if the miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency (POI) pathogenesis. METHODS: From January 2011 to December 2014, a total of 148 individuals with POI and 225 age-matched controls were collected from the Center for Reproductive Medicine, 1st Affiliated Hospital of Anhui Medical University (Hefei, China). Genotyping of miR-449b rs1006113 was performed using matrix-assisted laser desorption ionization time-of-flight-based mass spectrometry. RESULTS: Rs10061133 A>G is a highly conserved SNP locus in the mature area of miR-449b. Association analysis shows that the rs10061133 AA genotype is a risk factor for POI. CONCLUSIONS: Our study provides the first evidence that the miR-449b rs10061133 AA genotype is associated with POI risk.
OBJECTIVE: To determine if the miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency (POI) pathogenesis. METHODS: From January 2011 to December 2014, a total of 148 individuals with POI and 225 age-matched controls were collected from the Center for Reproductive Medicine, 1st Affiliated Hospital of Anhui Medical University (Hefei, China). Genotyping of miR-449brs1006113 was performed using matrix-assisted laser desorption ionization time-of-flight-based mass spectrometry. RESULTS:Rs10061133 A>G is a highly conserved SNP locus in the mature area of miR-449b. Association analysis shows that the rs10061133 AA genotype is a risk factor for POI. CONCLUSIONS: Our study provides the first evidence that the miR-449brs10061133 AA genotype is associated with POI risk.
Authors: HyungChul Rah; Ki Wha Chung; Ki Han Ko; Eun Sun Kim; Jung Oh Kim; Jung Hyun Sakong; Ji Hyang Kim; Woo Sik Lee; Nam Keun Kim Journal: PLoS One Date: 2017-05-10 Impact factor: 3.240