Literature DB >> 27552021

[Pontine reversible leucopathy in an AIDS patient associated with highly active antiretroviral therapy (HAART): Report of one case].

Luis Cartier, José Manuel Matamala, Alonso Yáñez.   

Abstract

Posterior reversible encephalopathy (PRES) is a condition characterized by T2 and FLAIR hyperintensities in magnetic resonance imaging (MRI) studies, localized preferentially in the occipital-parietal white matter regions. Pathological MRI images located in midbrain, pons, medulla and spinal cord, that could be asymptomatic, were recently included in this entity. These images are interpreted as vasogenic edema, which is caused by arterial hypertension or eclampsia, neurotoxicity related to immunosuppressive agents or chemotherapy, among other causes. We report a 25 years old asymptomatic male with AIDS, with normal blood pressure who after initiating highly active antiretroviral therapy (HAART) reported vertigo. The MRI showed a central pontine T2 hyperintensity with diffusion restriction, which was interpreted as a central pontine myelinolysis (CPM), but the lack of motor symptoms made improbable a real demyelination of the pons. The follow-up MRI revealed complete regression of the images. To our knowledge, this case could be the second report of a reversible leucopathy of the pons in a patient with AIDS, were the MRI images also simulated a CPM. This report extends the knowledge around the variability of the pathogenic interpretation of CPM images and their association with HAART.

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Year:  2016        PMID: 27552021     DOI: 10.4067/S0034-98872016000500018

Source DB:  PubMed          Journal:  Rev Med Chil        ISSN: 0034-9887            Impact factor:   0.553


  1 in total

Review 1.  Isolated pons involvement in Posterior Reversible Encephalopathy Syndrome: Case report and review of the literature.

Authors:  Mariangela Ferrara; Pietro Di Viesti; Vincenzo Inchingolo; Raffaela Rita Latino; Teresa Popolizio; Salvatore Angelo De Cosmo; Flavia Pugliese; Maurizio Angelo Leone
Journal:  eNeurologicalSci       Date:  2016-11-28
  1 in total

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