| Literature DB >> 27550322 |
Clara Shen1, Jacek L Kolanowski, Carmen M-N Tran, Amandeep Kaur, Mia C Akerfeldt, Matthew S Rahme, Trevor W Hambley, Elizabeth J New.
Abstract
Copper plays a key role in the modulation of cellular function, defence, and growth. Here we present InCCu1, a ratiometric fluorescent sensor for mitochondrial copper, which changes from red to blue emission in the presence of Cu(i). Employing this probe in microscopy and flow cytometry, we show that cisplatin-treated cells have an impaired ability to accumulate copper in the mitochondria.Entities:
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Year: 2016 PMID： 27550322 DOI： 10.1039/c6mt00083e
Source DB: PubMed Journal: Metallomics ISSN： 1756-5901 Impact factor: 4.526