Literature DB >> 27547160

Is Mold Toxicity Really a Problem for Our Patients? Part 2-Nonrespiratory Conditions.

Joseph Pizzorno, Ann Shippy.   

Abstract

In my last editorial, I addressed the respiratory effects of mold exposure. The surprising research shows that as many as 50% of residential and work environments have water damage1 and that mold toxicity should be considered in all patients with any chronic respiratory condition. This is especially true in adult-onset asthma, two-thirds of which appears to be caused by toxins released from water-damaged buildings. The carcinogenic effects of food-borne mold contamination are also well documented. Less clear is the role of indoor mold exposure in water-damaged buildings and its relationship to nonrespiratory conditions. As we look at the research on mold toxicity and toxins in general, we propose that the medical community (by all its names) has focused too much on the "yellow canaries" and missed the big picture that toxins have now become a primary driver of disease in the general population, not only among those most susceptible. The mold toxicity conundrum illustrates this issue quite well. As summarized in this editorial, there clearly is a portion of the population, the size of which is currently unknown, who experience neurological and/or immunological damage from mold toxicity. In addition, a substantial portion of the population experiences chronic respiratory problems from mold exposure. This does not mean we should stop paying attention to our more affected patients. Rather, we need to realize that almost everyone is being affected by toxins to some degree: molds, metals, solvents, persistent organic pollutants, etc.

Entities:  

Year:  2016        PMID: 27547160      PMCID: PMC4982651     

Source DB:  PubMed          Journal:  Integr Med (Encinitas)        ISSN: 1546-993X


  19 in total

Review 1.  Mold and mycotoxins: effects on the neurological and immune systems in humans.

Authors:  Andrew W Campbell; Jack D Thrasher; Michael R Gray; Aristo Vojdani
Journal:  Adv Appl Microbiol       Date:  2004       Impact factor: 5.086

2.  Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment.

Authors:  Enusha Karunasena; Michael D Larrañaga; Jan S Simoni; David R Douglas; David C Straus
Journal:  Mycopathologia       Date:  2010-06-13       Impact factor: 2.574

3.  Comparison of work-related symptoms and visual contrast sensitivity between employees at a severely water-damaged school and a school without significant water damage.

Authors:  Gregory Thomas; Nancy Clark Burton; Charles Mueller; Elena Page; Stephen Vesper
Journal:  Am J Ind Med       Date:  2012-05-07       Impact factor: 2.214

4.  A model to evaluate the cytotoxicity of the fungal volatile organic compound 1-octen-3-ol in human embryonic stem cells.

Authors:  Arati A Inamdar; Jennifer C Moore; Rick I Cohen; Joan Wennstrom Bennett
Journal:  Mycopathologia       Date:  2011-08-20       Impact factor: 2.574

5.  Acute effects of 1-octen-3-ol, a microbial volatile organic compound (MVOC)--an experimental study.

Authors:  Robert Wålinder; Lena Ernstgård; Dan Norbäck; Gunilla Wieslander; Gunnar Johanson
Journal:  Toxicol Lett       Date:  2008-07-25       Impact factor: 4.372

Review 6.  Public health impacts of foodborne mycotoxins.

Authors:  Felicia Wu; John D Groopman; James J Pestka
Journal:  Annu Rev Food Sci Technol       Date:  2014-01-09

7.  Drosophila melanogaster as a model to characterize fungal volatile organic compounds.

Authors:  Arati A Inamdar; Taslim Zaman; Shannon U Morath; David C Pu; Joan W Bennett
Journal:  Environ Toxicol       Date:  2012-11-09       Impact factor: 4.119

8.  Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses.

Authors:  Jamie H Rosenblum Lichtenstein; Yi-Hsiang Hsu; Igor M Gavin; Thomas C Donaghey; Ramon M Molina; Khristy J Thompson; Chih-Lin Chi; Bruce S Gillis; Joseph D Brain
Journal:  PLoS One       Date:  2015-05-26       Impact factor: 3.240

9.  Detection of mycotoxins in patients with chronic fatigue syndrome.

Authors:  Joseph H Brewer; Jack D Thrasher; David C Straus; Roberta A Madison; Dennis Hooper
Journal:  Toxins (Basel)       Date:  2013-04-11       Impact factor: 4.546

10.  Interference with mutagenic aflatoxin B1-induced checkpoints through antagonistic action of ochratoxin A in intestinal cancer cells: a molecular explanation on potential risk of crosstalk between carcinogens.

Authors:  Juil Kim; Seong-Hwan Park; Kee Hun Do; Dongwook Kim; Yuseok Moon
Journal:  Oncotarget       Date:  2016-06-28
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