Patompong Ungprasert1, Karn Wijarnpreecha2, Matthew J Koster3, Charat Thongprayoon2, Kenneth J Warrington3. 1. Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905. Electronic address: Ungprasert.Patompong@mayo.edu. 2. Department of Medicine, Bassett Medical Center, Cooperstown, NY. 3. Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905.
Abstract
OBJECTIVES: To investigate the risk of cerebrovascular accident (CVA) among patients with giant cell arteritis (GCA). METHODS: We conducted a systematic review and meta-analysis of cohort studies that reported relative risks, hazard ratios, or standardized incidence ratios comparing CVA risk in patients with GCA versus non-GCA comparators. Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: Eight studies with 17,919 patients with GCA were identified and included in our data analysis. The pooled risk ratio of CVA in patients with GCA versus non-GCA controls was 1.40 (95% CI: 1.27-1.56). The statistical heterogeneity was low with an I2 of 31%. CONCLUSIONS: Our study indicates a significantly increased risk of CVA among patients with GCA.
OBJECTIVES: To investigate the risk of cerebrovascular accident (CVA) among patients with giant cell arteritis (GCA). METHODS: We conducted a systematic review and meta-analysis of cohort studies that reported relative risks, hazard ratios, or standardized incidence ratios comparing CVA risk in patients with GCA versus non-GCA comparators. Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: Eight studies with 17,919 patients with GCA were identified and included in our data analysis. The pooled risk ratio of CVA in patients with GCA versus non-GCA controls was 1.40 (95% CI: 1.27-1.56). The statistical heterogeneity was low with an I2 of 31%. CONCLUSIONS: Our study indicates a significantly increased risk of CVA among patients with GCA.
Authors: Catalina Sanchez-Alvarez; Alexander S Hawkins; Matthew J Koster; Vance T Lehman; Cynthia S Crowson; Kenneth J Warrington Journal: ACR Open Rheumatol Date: 2020-07-22