BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently described life-threatening autoimmune disorder associated with a characteristic multi-stage neuropsychiatric syndrome. Although it is known that the majority of patients experience neuropsychological disturbance post-treatment, some aspects of the cognitive profile remain unclear. METHODS: This study sought to investigate patterns of cognitive functioning in a sample of anti-NMDAR encephalitis patients. Seven (6F:1M; mean age, 26.4 years; range, 16-37 years) treated patients completed a comprehensive set of neurocognitive and social functioning measures. Performance was analyzed using normative data (where available), and comparison with matched controls (10F:4M; mean age, 25.8 years; range, 16-38 years). RESULTS: Individual cognitive profiles ranged from within normal limits to extensive dysfunction. Relative to controls, the patient group's performance was affected in the domains of verbal/ visual memory, working memory, attention, processing speed, executive functioning, and social cognition. The patient group also reported significantly higher levels of anxiety compared to controls. CONCLUSIONS: These results add to the accumulating evidence that neurocognitive deficits, consistent with the distribution and functions of the NMDAR system can persist during recovery from anti-NMDAR encephalitis. This is the first study to provide evidence of performance decrements on measures of social cognition, including some involving theory of mind. (JINS, 2016, 22, 828-838).
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently described life-threatening autoimmune disorder associated with a characteristic multi-stage neuropsychiatric syndrome. Although it is known that the majority of patients experience neuropsychological disturbance post-treatment, some aspects of the cognitive profile remain unclear. METHODS: This study sought to investigate patterns of cognitive functioning in a sample of anti-NMDARencephalitispatients. Seven (6F:1M; mean age, 26.4 years; range, 16-37 years) treated patients completed a comprehensive set of neurocognitive and social functioning measures. Performance was analyzed using normative data (where available), and comparison with matched controls (10F:4M; mean age, 25.8 years; range, 16-38 years). RESULTS: Individual cognitive profiles ranged from within normal limits to extensive dysfunction. Relative to controls, the patient group's performance was affected in the domains of verbal/ visual memory, working memory, attention, processing speed, executive functioning, and social cognition. The patient group also reported significantly higher levels of anxiety compared to controls. CONCLUSIONS: These results add to the accumulating evidence that neurocognitive deficits, consistent with the distribution and functions of the NMDAR system can persist during recovery from anti-NMDARencephalitis. This is the first study to provide evidence of performance decrements on measures of social cognition, including some involving theory of mind. (JINS, 2016, 22, 828-838).
Entities:
Keywords:
Anti-N-methyl-D-aspartate receptor encephalitis; Cognition disorders; Neuropsychology; Social behavior; Theory of mind; Treatment outcome
Authors: Sarah L Ferri; Ashley A Pallathra; Hyong Kim; Holly C Dow; Praachi Raje; Mary McMullen; Warren B Bilker; Steven J Siegel; Ted Abel; Edward S Brodkin Journal: Genes Brain Behav Date: 2019-12-12 Impact factor: 3.449
Authors: Marienke A A M de Bruijn; Femke K Aarsen; Marielle P van Oosterhout; Marieke M van der Knoop; Coriene E Catsman-Berrevoets; Marco W J Schreurs; Danielle E M Bastiaansen; Peter A E Sillevis Smitt; Rinze F Neuteboom; Maarten J Titulaer Journal: Neurology Date: 2018-04-27 Impact factor: 9.910
Authors: James G Scott; David Gillis; Alex E Ryan; Hethal Hargovan; Nagaraj Gundarpi; Gemma McKeon; Sean Hatherill; Martin P Newman; Peter Parry; Kerri Prain; Sue Patterson; Richard C W Wong; Robert J Wilson; Stefan Blum Journal: BJPsych Open Date: 2018-03-16