Literature DB >> 27544511

Development of acute lymphoblastic leukemia with IgH-EPOR in a patient with secondary erythrocytosis.

Kenichi Sakamoto1,2, Seiji Tanaka3, Chihiro Tomoyasu4, Toshihiro Tomii4, Mio Yano3, Kazutaka Takagi5, Tsutsumi Yasuhiko6, Nobuhiko Uoshima6, Hiroshi Komatsu3, Toshihiko Imamura4.   

Abstract

We report the first patient to develop ALL with a fusion gene of the erythropoietin receptor (EPOR) with immunoglobulin heavy chain (IgH) 22 years after a diagnosis of secondary erythrocytosis with unknown etiology. The IgH-EPOR rearrangement is known to induce increased expression of EPOR, and activates EPO-associated signal pathways by exogenous EPO stimulation, resulting in the increased proliferation and survival of IgH-EPOR-positive leukemic cells. Interestingly, this case may provide supporting the possibility that IgH-EPOR-positive ALL has a growth advantage under sustained high concentrations of EPO.

Entities:  

Keywords:  Acute lymphoblastic leukemia; IgH-EPOR; Secondary erythrocytosis

Mesh：

Substances：

Year:  2016        PMID： 27544511     DOI： 10.1007/s12185-016-2083-2

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  11 in total

Review 1.  The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression.

Authors:  Benjamin D Hedley; Alison L Allan; Anargyros Xenocostas
Journal:  Clin Cancer Res       Date:  2011-07-12       Impact factor: 12.531

2.  A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin.

Authors:  L J Russell; D G De Castro; M Griffiths; N Telford; O Bernard; R Panzer-Grümayer; O Heidenreich; A V Moorman; C J Harrison
Journal:  Leukemia       Date:  2008-09-25       Impact factor: 11.528

3.  Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.

Authors:  Kathryn G Roberts; Ryan D Morin; Jinghui Zhang; Martin Hirst; Yongjun Zhao; Xiaoping Su; Shann-Ching Chen; Debbie Payne-Turner; Michelle L Churchman; Richard C Harvey; Xiang Chen; Corynn Kasap; Chunhua Yan; Jared Becksfort; Richard P Finney; David T Teachey; Shannon L Maude; Kane Tse; Richard Moore; Steven Jones; Karen Mungall; Inanc Birol; Michael N Edmonson; Ying Hu; Kenneth E Buetow; I-Ming Chen; William L Carroll; Lei Wei; Jing Ma; Maria Kleppe; Ross L Levine; Guillermo Garcia-Manero; Eric Larsen; Neil P Shah; Meenakshi Devidas; Gregory Reaman; Malcolm Smith; Steven W Paugh; William E Evans; Stephan A Grupp; Sima Jeha; Ching-Hon Pui; Daniela S Gerhard; James R Downing; Cheryl L Willman; Mignon Loh; Stephen P Hunger; Marco A Marra; Charles G Mullighan
Journal:  Cancer Cell       Date:  2012-08-14       Impact factor: 31.743

4.  Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.

Authors:  Ilaria Iacobucci; Yongjin Li; Kathryn G Roberts; Stephanie M Dobson; Jaeseung C Kim; Debbie Payne-Turner; Richard C Harvey; Marcus Valentine; Kelly McCastlain; John Easton; Donald Yergeau; Laura J Janke; Ying Shao; I-Ming L Chen; Michael Rusch; Sasan Zandi; Steven M Kornblau; Marina Konopleva; Elias Jabbour; Elisabeth M Paietta; Jacob M Rowe; Ching-Hon Pui; Julie Gastier-Foster; Zhaohui Gu; Shalini Reshmi; Mignon L Loh; Janis Racevskis; Martin S Tallman; Peter H Wiernik; Mark R Litzow; Cheryl L Willman; John D McPherson; James R Downing; Jinghui Zhang; John E Dick; Stephen P Hunger; Charles G Mullighan
Journal:  Cancer Cell       Date:  2016-02-08       Impact factor: 31.743

5.  Absence of functional EpoR expression in human tumor cell lines.

Authors:  Susan Swift; Aaron R Ellison; Paul Kassner; Ian McCaffery; John Rossi; Angus M Sinclair; C Glenn Begley; Steven Elliott
Journal:  Blood       Date:  2010-02-02       Impact factor: 22.113

6.  Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia.

Authors:  Hagop Kantarjian; Deborah Thomas; Susan O'Brien; Jorge Cortes; Francis Giles; Sima Jeha; Carlos E Bueso-Ramos; Sherry Pierce; Jianqin Shan; Charles Koller; Miloslav Beran; Michael Keating; Emil J Freireich
Journal:  Cancer       Date:  2004-12-15       Impact factor: 6.860

7.  A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study.

Authors:  Monique L Den Boer; Marjon van Slegtenhorst; Renée X De Menezes; Meyling H Cheok; Jessica G C A M Buijs-Gladdines; Susan T C J M Peters; Laura J C M Van Zutven; H Berna Beverloo; Peter J Van der Spek; Gaby Escherich; Martin A Horstmann; Gritta E Janka-Schaub; Willem A Kamps; William E Evans; Rob Pieters
Journal:  Lancet Oncol       Date:  2009-01-08       Impact factor: 41.316

8.  Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

Authors:  Kathryn G Roberts; Yongjin Li; Debbie Payne-Turner; Richard C Harvey; Yung-Li Yang; Deqing Pei; Kelly McCastlain; Li Ding; Charles Lu; Guangchun Song; Jing Ma; Jared Becksfort; Michael Rusch; Shann-Ching Chen; John Easton; Jinjun Cheng; Kristy Boggs; Natalia Santiago-Morales; Ilaria Iacobucci; Robert S Fulton; Ji Wen; Marcus Valentine; Cheng Cheng; Steven W Paugh; Meenakshi Devidas; I-Ming Chen; Shalini Reshmi; Amy Smith; Erin Hedlund; Pankaj Gupta; Panduka Nagahawatte; Gang Wu; Xiang Chen; Donald Yergeau; Bhavin Vadodaria; Heather Mulder; Naomi J Winick; Eric C Larsen; William L Carroll; Nyla A Heerema; Andrew J Carroll; Guy Grayson; Sarah K Tasian; Andrew S Moore; Frank Keller; Melissa Frei-Jones; James A Whitlock; Elizabeth A Raetz; Deborah L White; Timothy P Hughes; Jaime M Guidry Auvil; Malcolm A Smith; Guido Marcucci; Clara D Bloomfield; Krzysztof Mrózek; Jessica Kohlschmidt; Wendy Stock; Steven M Kornblau; Marina Konopleva; Elisabeth Paietta; Ching-Hon Pui; Sima Jeha; Mary V Relling; William E Evans; Daniela S Gerhard; Julie M Gastier-Foster; Elaine Mardis; Richard K Wilson; Mignon L Loh; James R Downing; Stephen P Hunger; Cheryl L Willman; Jinghui Zhang; Charles G Mullighan
Journal:  N Engl J Med       Date:  2014-09-11       Impact factor: 91.245

9.  IGH@ translocations are prevalent in teenagers and young adults with acute lymphoblastic leukemia and are associated with a poor outcome.

Authors:  Lisa J Russell; Amir Enshaei; Lisa Jones; Amy Erhorn; Dino Masic; Helen Bentley; Karl S Laczko; Adele K Fielding; Anthony H Goldstone; Nicholas Goulden; Christopher D Mitchell; Rachel Wade; Ajay Vora; Anthony V Moorman; Christine J Harrison
Journal:  J Clin Oncol       Date:  2014-04-07       Impact factor: 44.544

10.  Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan.

Authors:  T Imamura; N Kiyokawa; M Kato; C Imai; Y Okamoto; M Yano; K Ohki; Y Yamashita; Y Kodama; A Saito; M Mori; S Ishimaru; T Deguchi; Y Hashii; Y Shimomura; T Hori; K Kato; H Goto; C Ogawa; K Koh; T Taki; A Manabe; A Sato; A Kikuta; S Adachi; K Horibe; A Ohara; A Watanabe; Y Kawano; E Ishii; H Shimada
Journal:  Blood Cancer J       Date:  2016-05-13       Impact factor: 11.037
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