Literature DB >> 2754393

Tumor necrosis factor identified in multiple sclerosis brain.

F M Hofman1, D R Hinton, K Johnson, J E Merrill.   

Abstract

Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases were analyzed using immunocytochemical techniques for the presence of TNF. In brain lesions in MS, and subacute sclerosing panencephalitis, TNF+ cells were demonstrated. At the lesion site in MS, TNF+ staining is associated with both astrocytes and macrophages. These observations were not made in Alzheimer's disease or normal brain tissue. The presence of TNF in MS lesions suggests a significant role for cytokines and the immune response in disease progression.

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Year:  1989        PMID： 2754393      PMCID： PMC2189402          DOI： 10.1084/jem.170.2.607

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  14 in total

1.  Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis.

Authors:  J W Prineas; R G Wright
Journal:  Lab Invest       Date:  1978-04       Impact factor: 5.662

2.  Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

Authors:  F M Hofman; R I von Hanwehr; C A Dinarello; S B Mizel; D Hinton; J E Merrill
Journal:  J Immunol       Date:  1986-05-01       Impact factor: 5.422

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Authors:  A Fontana; W Fierz; H Wekerle
Journal:  Nature       Date:  1984 Jan 19-25       Impact factor: 49.962

4.  Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?

Authors:  A Fontana; E Weber; J M Dayer
Journal:  J Immunol       Date:  1984-10       Impact factor: 5.422

5.  Analysis of B-cell antigens in normal reactive lymphoid tissue using four B-cell monoclonal antibodies.

Authors:  F M Hofman; E Yanagihara; B Byrne; R Billing; S Baird; D Frisman; C R Taylor
Journal:  Blood       Date:  1983-10       Impact factor: 22.113

6.  Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells.

Authors:  K Frei; C Siepl; P Groscurth; S Bodmer; C Schwerdel; A Fontana
Journal:  Eur J Immunol       Date:  1987-09       Impact factor: 5.532

7.  In vitro study of mediators of inflammation in multiple sclerosis.

Authors:  J E Merrill; S R Strom; G W Ellison; L W Myers
Journal:  J Clin Immunol       Date:  1989-03       Impact factor: 8.317

8.  Inducible expression of H-2 and Ia antigens on brain cells.

Authors:  G H Wong; P F Bartlett; I Clark-Lewis; F Battye; J W Schrader
Journal:  Nature       Date:  1984 Aug 23-29       Impact factor: 49.962

9.  Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

Authors:  A Fontana; F Kristensen; R Dubs; D Gemsa; E Weber
Journal:  J Immunol       Date:  1982-12       Impact factor: 5.422

10.  Effect of tumor necrosis factor alpha on mitogen-activated human B cells.

Authors:  J H Kehrl; A Miller; A S Fauci
Journal:  J Exp Med       Date:  1987-09-01       Impact factor: 14.307
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  173 in total

Review 1.  The role of TNFalpha and lymphotoxin in demyelinating disease.

Authors:  C Lock; J Oksenberg; L Steinman
Journal:  Ann Rheum Dis       Date:  1999-11       Impact factor: 19.103

Review 2.  Antigen specific immunotherapy of multiple sclerosis.

Authors:  L Steinman; P Conlon
Journal:  J Clin Immunol       Date:  2001-03       Impact factor: 8.317

3.  Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology.

Authors:  B Bonetti; C Stegagno; B Cannella; N Rizzuto; G Moretto; C S Raine
Journal:  Am J Pathol       Date:  1999-11       Impact factor: 4.307

4.  Induction of oligodendrocyte apoptosis by C2-ceramide.

Authors:  J N Larocca; M Farooq; W T Norton
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

5.  trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein.

Authors:  H Albrecht; A N Shakhov; C V Jongeneel
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

6.  Neurological complications of biologic therapy in psoriasis: a review.

Authors:  Mark Bechtel; Catherine Sanders; Ann Bechtel
Journal:  J Clin Aesthet Dermatol       Date:  2009-11

7.  Complementary and alternative medicine for the treatment of multiple sclerosis.

Authors:  Vijayshree Yadav; Lynne Shinto; Dennis Bourdette
Journal:  Expert Rev Clin Immunol       Date:  2010-05       Impact factor: 4.473

8.  Prolonged dynamic clinico-immunological observation of 85 patients with definite multiple sclerosis: first steps towards monitoring process activity.

Authors:  E I Gusev; T L Demina; A N Boiko; B V Pinegin
Journal:  J Neurol       Date:  1994-07       Impact factor: 4.849

9.  Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

Authors:  L Probert; K Akassoglou; M Pasparakis; G Kontogeorgos; G Kollias
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

10.  Dual expression of CD45RA and CD45RO isoforms on myelin basic protein-specific CD4+ T-cell lines in multiple sclerosis.

Authors:  Y Qin; S Van Den Noort; J Kurt; S Gupta
Journal:  J Clin Immunol       Date:  1993-03       Impact factor: 8.317
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