Jeremy Howick1, Patrick M Bossuyt2, Jochen W L Cals3. 1. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. 2. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 3. Department of Family Medicine, School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, The Netherlands.