Literature DB >> 2754341

A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.

P P Van Veldhoven1, R J Foglesong, R M Bell.   

Abstract

A procedure is described to prepare sphingosine-1-phosphate by treatment of sphingosylphosphocholine with phospholipase D, isolated from Streptomyces chromofuscus. The phosphorylated long chain bases were purified by selective precipitation and differential extraction. Milligram quantities can be obtained in a yield of about 70%. Application of the procedure to dihydrosphingosylphosphocholine results in the synthesis of dihydrosphingosine-1-phosphate.

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Year:  1989        PMID： 2754341

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  7 in total

1.  Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry.

Authors:  Kiyoshi Itagaki; Carl J Hauser
Journal:  J Biol Chem       Date:  2003-05-13       Impact factor: 5.157

Review 2.  Sphingolipid metabolites: members of a new class of lipid second messengers.

Authors:  S Spiegel; S Milstien
Journal:  J Membr Biol       Date:  1995-08       Impact factor: 1.843

3.  Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1.

Authors:  A Berger; D Rosenthal; S Spiegel
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

4.  Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

Authors:  Y Sadahira; F Ruan; S Hakomori; Y Igarashi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

5.  Identification and subcellular localization of sphinganine-phosphatases in rat liver.

Authors:  P De Ceuster; G P Mannaerts; P P Van Veldhoven
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

6.  Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis.

Authors:  K Jalink; T Hengeveld; S Mulder; F R Postma; M F Simon; H Chap; G A van der Marel; J H van Boom; W J van Blitterswijk; W H Moolenaar
Journal:  Biochem J       Date:  1995-04-15       Impact factor: 3.857

7.  Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

Authors:  H Zhang; N N Desai; A Olivera; T Seki; G Brooker; S Spiegel
Journal:  J Cell Biol       Date:  1991-07       Impact factor: 10.539
  7 in total

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