Cecilie Scheuer1, Hans-Christian Pommergaard2, Jacob Rosenberg3, Ismail Gögenur4. 1. Køge Hospital - University of Copenhagen, Department of Surgery, Lykkebækvej 1, DK-4600 Køge, Denmark. Electronic address: cili_scheuer@hotmail.com. 2. Herlev Hospital - University of Copenhagen, Department of Surgery, Herlev Ringvej 75, DK- 2730 Herlev, Denmark; Hvidovre Hospital - University of Copenhagen, Department of Surgery, Kettegård Alle 30, DK - 2650 Hvidovre, Denmark. 3. Herlev Hospital - University of Copenhagen, Department of Surgery, Herlev Ringvej 75, DK- 2730 Herlev, Denmark. 4. Køge Hospital - University of Copenhagen, Department of Surgery, Lykkebækvej 1, DK-4600 Køge, Denmark.
Abstract
BACKGROUND:Ultraviolet radiation (UVR) by sunlight results in an increasing number of skin conditions. Earlier studies have suggested a protective effect of topical treatment with the pineal hormone melatonin. However, this protective effect has never been evaluated in natural sunlight, and the optimal dosing has not been clarified. OBJECTIVE: The aim of this study was to investigate the sun protective effect of topical treatment with three different doses of melatonin (0.5%, 2.5%, 12.5%) against erythema induced by natural sunlight. METHOD: The study was a randomized, placebo-controlled, double-blind study in healthy volunteers. Twenty-three healthy volunteers, 8 male and 15 female, were enrolled. The protective effect of three different doses of melatonin cream (0.5%, 2.5%, 12.5%) against erythema induced by natural sunlight was tested. All participants had their backs exposed to sun from 1:22 PM to 2:02 PM local time and UV-index was 9. Primary outcome was reduction in erythema evaluated by chromatography after sun exposure, when treated with topical melatonin cream (0.5%, 2.5%, 12.5%) versus placebo and no treatment. The erythema reaction was evaluated with chromatography and visual scoring at baseline, one, four, eight and 24h after exposure. RESULTS: Significant difference in erythema formation was found between areas treated with melatonin cream 12.5% and areas receiving placebo or no treatment (repeated measures ANOVA p=0.001). No differences were found between placebo and the 0.5% and 2.5% concentrations. CONCLUSION: Application of melatonin cream 12.5% protects against natural sunlight induced erythema.
RCT Entities:
BACKGROUND: Ultraviolet radiation (UVR) by sunlight results in an increasing number of skin conditions. Earlier studies have suggested a protective effect of topical treatment with the pineal hormone melatonin. However, this protective effect has never been evaluated in natural sunlight, and the optimal dosing has not been clarified. OBJECTIVE: The aim of this study was to investigate the sun protective effect of topical treatment with three different doses of melatonin (0.5%, 2.5%, 12.5%) against erythema induced by natural sunlight. METHOD: The study was a randomized, placebo-controlled, double-blind study in healthy volunteers. Twenty-three healthy volunteers, 8 male and 15 female, were enrolled. The protective effect of three different doses of melatonin cream (0.5%, 2.5%, 12.5%) against erythema induced by natural sunlight was tested. All participants had their backs exposed to sun from 1:22 PM to 2:02 PM local time and UV-index was 9. Primary outcome was reduction in erythema evaluated by chromatography after sun exposure, when treated with topical melatonin cream (0.5%, 2.5%, 12.5%) versus placebo and no treatment. The erythema reaction was evaluated with chromatography and visual scoring at baseline, one, four, eight and 24h after exposure. RESULTS: Significant difference in erythema formation was found between areas treated with melatonin cream 12.5% and areas receiving placebo or no treatment (repeated measures ANOVA p=0.001). No differences were found between placebo and the 0.5% and 2.5% concentrations. CONCLUSION: Application of melatonin cream 12.5% protects against natural sunlight induced erythema.
Authors: Cezary Skobowiat; Anna A Brożyna; Zorica Janjetovic; Saowanee Jeayeng; Allen S W Oak; Tae-Kang Kim; Uraiwan Panich; Russel J Reiter; Andrzej T Slominski Journal: J Pineal Res Date: 2018-05-21 Impact factor: 13.007
Authors: Andrzej T Slominski; Ruediger Hardeland; Michal A Zmijewski; Radomir M Slominski; Russel J Reiter; Ralf Paus Journal: J Invest Dermatol Date: 2018-02-07 Impact factor: 8.551
Authors: Joanna Stefan; Tae-Kang Kim; Fiona Schedel; Zorica Janjetovic; David K Crossman; Kerstin Steinbrink; Radomir M Slominski; Jaroslaw Zmijewski; Meri K Tulic; Russel J Reiter; Konrad Kleszczyński; Andrzej T Slominski Journal: Antioxidants (Basel) Date: 2021-04-17