Leolin Katsidzira1, Eric Chokunonga2, Innocent T Gangaidzo3, Simbarashe Rusakaniko4, Margaret Borok5, Zvifadzo Matsena-Zingoni6, Sandie Thomson7, Raj Ramesar8, Jonathan A Matenga3. 1. Department of Medicine, College of Health Sciences, University of Zimbabwe, P.O. Box A178, Avondale, Harare, Zimbabwe; Division of Gastroenterology, Department of Medicine, University of Cape Town, Cape Town, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa. Electronic address: lkatsidzira@hotmail.com. 2. Zimbabwe National Cancer Registry, P.O. Box A449, Avondale, Harare, Zimbabwe. 3. Department of Medicine, College of Health Sciences, University of Zimbabwe, P.O. Box A178, Avondale, Harare, Zimbabwe. 4. Department of Community Medicine, College of Health Sciences, University of Zimbabwe, P.O. Box A178, Avondale, Harare, Zimbabwe. 5. Department of Medicine, College of Health Sciences, University of Zimbabwe, P.O. Box A178, Avondale, Harare, Zimbabwe; Zimbabwe National Cancer Registry, P.O. Box A449, Avondale, Harare, Zimbabwe. 6. National Institute of Health Research, Cnr Mazowe/Josiah Tongogara street, Harare, Zimbabwe. 7. Division of Gastroenterology, Department of Medicine, University of Cape Town, Cape Town, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa. 8. MRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
Abstract
BACKGROUND: Data on colorectal cancer (CRC) in sub-Saharan Africa is mainly based on hospital series which suggest low incidence and frequent early onset cancers. This study characterises colorectal cancer in a population-based cancer registry in Zimbabwe. METHODS: Cases of CRC recorded by the Zimbabwe National Cancer Registry between 2003 and 2012 were analysed. Demographic and pathological characteristics were compared according to ethnicity and age. Trends in age standardised incidence rates (ASR) were determined. RESULTS: There were 886 and 216 cases of CRC among black Africans and Caucasians respectively, and 26% of the black Africans were younger than 40 years. Signet ring cell carcinomas were more common among black Africans compared to Caucasians (4% vs 1%, p=0.027). ASR increased by 1.9%/year and 3.9%/year among black African males and females respectively. CONCLUSION: CRC incidence is rising among black Africans and has unique demographic and pathological characteristics.
BACKGROUND: Data on colorectal cancer (CRC) in sub-Saharan Africa is mainly based on hospital series which suggest low incidence and frequent early onset cancers. This study characterises colorectal cancer in a population-based cancer registry in Zimbabwe. METHODS: Cases of CRC recorded by the Zimbabwe National Cancer Registry between 2003 and 2012 were analysed. Demographic and pathological characteristics were compared according to ethnicity and age. Trends in age standardised incidence rates (ASR) were determined. RESULTS: There were 886 and 216 cases of CRC among black Africans and Caucasians respectively, and 26% of the black Africans were younger than 40 years. Signet ring cell carcinomas were more common among black Africans compared to Caucasians (4% vs 1%, p=0.027). ASR increased by 1.9%/year and 3.9%/year among black African males and females respectively. CONCLUSION: CRC incidence is rising among black Africans and has unique demographic and pathological characteristics.
Authors: Avinash Sharma; Olusegun I Alatise; Adewale O Adisa; Olukayode A Arowolo; Olalekan Olasehinde; Olusola C Famurewa; Adeleye D Omisore; A O Komolafe; O Olaofe; Aba I Katung; Ayoola D Ibikunle; Ayoola A Egberongbe; Samuel A Olatoke; S O Agodirin; A O Adesiyun; Ademola Adeyeye; K Ibrahim; O A Kolawole; O L Idris; M O Adejumobi; Adebowale I Ajayi; Akinwumi O Olakanmi; Jeremy C Constable; Ken Seier; Mithat Gonen; Murray F Brennan; T Peter Kingham Journal: J Surg Oncol Date: 2019-11-19 Impact factor: 3.454
Authors: Norah Alsadhan; Alaa Almaiman; Mar Pujades-Rodriguez; Cathy Brennan; Farag Shuweihdi; Sultana A Alhurishi; Robert M West Journal: BMC Med Res Methodol Date: 2022-05-19 Impact factor: 4.612