Khaled K Abu-Amero1,2, Altaf A Kondkar1, Ahmed Mousa1, Faisal A Almobarak1, Abdullah Alawad3, Saleh Altuwaijri4,5, Tahira Sultan1, Taif A Azad1, Saleh A Al-Obeidan1. 1. 1 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia . 2. 2 Department of Ophthalmology, College of Medicine, University of Florida , Jacksonville, Florida. 3. 3 National Center for Stem Cell Technology (NCSCT), Life Sciences and Environmental Research Institute , King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia . 4. 4 Clinical Research Laboratory, SAAD Research and Development Center, SAAD Specialist Hospital , Al Khobar, Saudi Arabia . 5. 5 Veterinary College, Qassim University , Qassim, Saudi Arabia .
Abstract
AIMS: To investigate whether the polymorphism rs1063192 (A>G) in the cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene is a risk factor for primary open-angle glaucoma (POAG). METHOD: A case-control study was conducted wherein we genotyped 87 unrelated POAG cases and 94 control subjects from Saudi Arabia using the Taq-Man® assay. RESULTS: The minor allele frequency was 0.20 in POAG cases and 0.21 in controls. Both the genotype and allele frequencies were not significantly different between cases and controls. No significant association was found between genotypes and glaucoma clinical indices, except that the mutant homozygous genotype (G/G) was associated with the family history of glaucoma (p = 0.024). CONCLUSION: Polymorphism rs1063192 in CDKN2B is not a risk factor for POAG in Saudi cohort.
AIMS: To investigate whether the polymorphism rs1063192 (A>G) in the cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene is a risk factor for primary open-angle glaucoma (POAG). METHOD: A case-control study was conducted wherein we genotyped 87 unrelated POAG cases and 94 control subjects from Saudi Arabia using the Taq-Man® assay. RESULTS: The minor allele frequency was 0.20 in POAG cases and 0.21 in controls. Both the genotype and allele frequencies were not significantly different between cases and controls. No significant association was found between genotypes and glaucoma clinical indices, except that the mutant homozygous genotype (G/G) was associated with the family history of glaucoma (p = 0.024). CONCLUSION: Polymorphism rs1063192 in CDKN2B is not a risk factor for POAG in Saudi cohort.
Entities:
Keywords:
CDKN2B; Saudi Arabia; genetics; primary open angle glaucoma; rs1063192
Authors: Altaf A Kondkar; Taif A Azad; Tahira Sultan; Essam A Osman; Faisal A Almobarak; Saleh A Al-Obeidan Journal: PLoS One Date: 2020-01-08 Impact factor: 3.240
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