Seungjin Lim1,2, Doo Ryeon Chung3, Yeon-Sook Kim4, Kyung Mok Sohn4, Seung-Ji Kang5, Sook-In Jung5, Shin-Woo Kim6, Hyun Ha Chang6, Seung Soon Lee7, In-Gyu Bae8, Chisook Moon9, Ji-Young Rhee10, Jin Seo Lee11, Hyun Kyun Ki12, Hyun Ah Kim13, Seong Yeol Ryu13, Joon-Sup Yeom14, Jun Seong Son15, Soo-Youn Moon15, Ki Tae Kwon16, Hyuck Lee17, Sang Taek Heo18, Cheol-In Kang1, Kyong Ran Peck1, Jae-Hoon Song1. 1. Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. 2. Department of Internal Medicine, Dongnam Institution of Radiological and Medical Sciences, Busan, Korea. 3. Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. iddrchung@gmail.com. 4. Division of Infectious Diseases, Chungnam National University School of Medicine, Daejeon, Korea. 5. Division of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea. 6. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. 7. Division of Infectious Diseases, Hallym University Sacred Heart Hospital, Anyang, Korea. 8. Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. 9. Division of Infectious Diseases, Inje University Busan Paik Hospital, Busan, Korea. 10. Division of Infectious Diseases, Dankook University Hospital, Cheonan, Korea. 11. Division of Infectious Diseases, Kangdong Sacred Heart Hospital, Seoul, Korea. 12. Division of Infectious Diseases, Konkuk University Hospital, Seoul, Korea. 13. Division of Infectious Diseases, Keimyung University Dongsan Medical Center, Daegu, Korea. 14. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. 15. Division of Infectious Diseases, Kyung Hee University Hospital at Gangdong, Seoul, Korea. 16. Division of Infectious Diseases, Daegu Fatima Hospital, Daegu, Korea. 17. Division of Infectious Diseases, Dong-A University Hospital, Busan, Korea. 18. Division of Infectious Diseases, Jeju National University School of Medicine, Jeju, Korea.
Abstract
PURPOSE: Various immunocompromised conditions increase the risk of meningitis caused by Listeria monocytogenes. However, the relative importance of these risk factors has not been well established. We determined the risk factors that predict meningitis due to L. monocytogenes compared to that caused by Streptococcus pneumoniae. METHODS: A nationwide multicenter case-control study was conducted in Korea. Cases of meningitis caused by L. monocytogenes between 1998 and 2013 were included. Patients with pneumococcal meningitis were included as controls. Multivariate logistic regression analysis was used to predict the risk factors of Listeria meningitis. RESULTS: A total of 36 cases and 113 controls were enrolled. The most significant predictive risk factor of Listeria meningitis was a prior history of receiving immunosuppressive therapy (odds ratio 8.12, 95 % CI 2.47-26.69). Chronic liver disease was the second most important predictive risk factor (OR 5.03, 95 % CI 1.56-16.22). Delaying appropriate antibiotic therapy by more than 6 h (hazard ratio 2.78) and fatal underlying disease (hazard ratio 2.88) were associated with increased mortality. CONCLUSIONS: Patients with a prior history of receiving immunosuppressive therapy within 1 month and chronic liver disease have 8.1-fold and 5-fold increased risk of meningitis by L. monocytogenes compared to S. pneumoniae, respectively.
PURPOSE: Various immunocompromised conditions increase the risk of meningitis caused by Listeria monocytogenes. However, the relative importance of these risk factors has not been well established. We determined the risk factors that predict meningitis due to L. monocytogenes compared to that caused by Streptococcus pneumoniae. METHODS: A nationwide multicenter case-control study was conducted in Korea. Cases of meningitis caused by L. monocytogenes between 1998 and 2013 were included. Patients with pneumococcal meningitis were included as controls. Multivariate logistic regression analysis was used to predict the risk factors of Listeria meningitis. RESULTS: A total of 36 cases and 113 controls were enrolled. The most significant predictive risk factor of Listeria meningitis was a prior history of receiving immunosuppressive therapy (odds ratio 8.12, 95 % CI 2.47-26.69). Chronic liver disease was the second most important predictive risk factor (OR 5.03, 95 % CI 1.56-16.22). Delaying appropriate antibiotic therapy by more than 6 h (hazard ratio 2.78) and fatal underlying disease (hazard ratio 2.88) were associated with increased mortality. CONCLUSIONS:Patients with a prior history of receiving immunosuppressive therapy within 1 month and chronic liver disease have 8.1-fold and 5-fold increased risk of meningitis by L. monocytogenes compared to S. pneumoniae, respectively.
Authors: Allan R Tunkel; Barry J Hartman; Sheldon L Kaplan; Bruce A Kaufman; Karen L Roos; W Michael Scheld; Richard J Whitley Journal: Clin Infect Dis Date: 2004-10-06 Impact factor: 9.079
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Authors: S-Y Moon; D R Chung; S-W Kim; H H Chang; H Lee; D S Jung; Y-S Kim; S I Jung; S Y Ryu; S T Heo; C Moon; H K Ki; J S Son; K T Kwon; S Y Shin; J S Lee; S S Lee; J-Y Rhee; J-A Lee; M K Joung; H S Cheong; K R Peck; J-H Song Journal: Eur J Clin Microbiol Infect Dis Date: 2010-05-01 Impact factor: 3.267
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