Literature DB >> 27540422

Radiolabeled Phosphonium Salts as Mitochondrial Voltage Sensors for Positron Emission Tomography Myocardial Imaging Agents.

Dong-Yeon Kim1, Jung-Joon Min1.   

Abstract

Despite substantial advances in the diagnosis of cardiovascular disease, (18)F-labeled positron emission tomography (PET) radiopharmaceuticals remain necessary to diagnose heart disease because clinical use of current PET tracers is limited by their short half-life. Lipophilic cations such as phosphonium salts penetrate the mitochondrial membranes and accumulate in mitochondria of cardiomyocytes in response to negative inner-transmembrane potentials. Radiolabeled tetraphenylphosphonium cation derivatives have been developed as myocardial imaging agents for PET. In this review, a general overview of these radiotracers, including their radiosynthesis, in vivo characterization, and evaluation is provided and clinical perspectives are discussed.

Entities:  

Keywords:  18F-Fluoroalkylphosphonium cations; Mitochondrial voltage sensors; Myocardial imaging agents; Positron emission tomography; Tetraphenylphosphonium cation derivatives

Year:  2016        PMID： 27540422      PMCID： PMC4977252          DOI： 10.1007/s13139-016-0397-x

Source DB:  PubMed          Journal:  Nucl Med Mol Imaging        ISSN： 1869-3474


  46 in total

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Review 2.  Positron emission tomography and molecular imaging.

Authors:  J Knuuti; F M Bengel
Journal:  Heart       Date:  2008-03       Impact factor: 5.994

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4.  Synthesis of [¹⁸F]-labeled (2-(2-fluoroethoxy)ethyl)triphenylphosphonium cation as a potential agent for myocardial imaging using positron emission tomography.

Authors:  Dong-Yeon Kim; Hee-Jung Kim; Kook-Hyun Yu; Jung-Joon Min
Journal:  Bioorg Med Chem Lett       Date:  2011-11-10       Impact factor: 2.823

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Review 6.  Isolated heart perfusion according to Langendorff---still viable in the new millennium.

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7.  Activation energy for permeation of phosphonium cations through phospholipid bilayer membrane.

Authors:  A Ono; S Miyauchi; M Demura; T Asakura; N Kamo
Journal:  Biochemistry       Date:  1994-04-12       Impact factor: 3.162

8.  Effects of targeting moiety, linker, bifunctional chelator, and molecular charge on biological properties of 64Cu-labeled triphenylphosphonium cations.

Authors:  Young-Seung Kim; Chang-Tong Yang; Jianjun Wang; Lijun Wang; Zi-Bo Li; Xiaoyuan Chen; Shuang Liu
Journal:  J Med Chem       Date:  2008-04-18       Impact factor: 7.446

9.  A study of the liver-heart artifact in emission tomography.

Authors:  J Nuyts; P Dupont; V Van den Maegdenbergh; S Vleugels; P Suetens; L Mortelmans
Journal:  J Nucl Med       Date:  1995-01       Impact factor: 10.057

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Authors:  Joseph T Knapper; Nima Ghasemzadeh; Mohamed Khayata; Sulay P Patel; Arshed A Quyyumi; Shanthi Mendis; George A Mensah; Kathryn Taubert; Laurence S Sperling
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Authors:  Jacek Zielonka; Joy Joseph; Adam Sikora; Micael Hardy; Olivier Ouari; Jeannette Vasquez-Vivar; Gang Cheng; Marcos Lopez; Balaraman Kalyanaraman
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Review 3.  KSNM60: The History of Radiopharmaceutical Sciences in Korea.

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Review 4.  Research Progress on 18F-Labeled Agents for Imaging of Myocardial Perfusion with Positron Emission Tomography.

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