Literature DB >> 27540005

Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus.

Jinyan Liu1, Khader Ghneim2, Devin Sok3, William J Bosche4, Yuan Li4, Elizabeth Chipriano4, Brian Berkemeier4, Kelli Oswald4, Erica Borducchi1, Crystal Cabral1, Lauren Peter1, Amanda Brinkman1, Mayuri Shetty1, Jessica Jimenez1, Jade Mondesir1, Benjamin Lee1, Patricia Giglio1, Abishek Chandrashekar1, Peter Abbink1, Arnaud Colantonio5, Courtney Gittens6, Chantelle Baker6, Wendeline Wagner6, Mark G Lewis6, Wenjun Li7, Rafick-Pierre Sekaly2, Jeffrey D Lifson4, Dennis R Burton8, Dan H Barouch9.   

Abstract

HIV-1-specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naïve hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.
Copyright © 2016, American Association for the Advancement of Science.

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Year:  2016        PMID： 27540005      PMCID： PMC5237379          DOI： 10.1126/science.aag0491

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-30       Impact factor: 11.205

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Journal:  Nature       Date:  2013-09-11       Impact factor: 49.962

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Journal:  Nature       Date:  2013-10-30       Impact factor: 49.962

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7.  Harnessing Novel Imaging Approaches to Guide HIV Prevention and Cure Discoveries-A National Institutes of Health and Global HIV Vaccine Enterprise 2017 Meeting Report.

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9.  Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia.

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