Gönül Çatlı1, Tuncay Küme2, Hale Ünver Tuhan3, Ahmet Anık4, Özlem Gürsoy Çalan2, Ece Böber3, Ayhan Abacı3. 1. Department of Pediatric Endocrinology, Katip Celebi University, Faculty of Medicine, Izmir. Electronic address: gonulcatli@gmail.com. 2. Department of Biochemistry, Dokuz Eylul University, Faculty of Medicine, Izmir. 3. Department of Pediatric Endocrinology, Dokuz Eylul University, Faculty of Medicine, Izmir. 4. Department of Pediatric Endocrinology, Adnan Menderes University, Faculty of Medicine, Aydın.
Abstract
OBJECTIVE: This study aimed to investigate the relationship between serum irisin level and metabolic and anthropometric parameters in obese children. METHODS: The study included 36 obese children with a body mass index (BMI) of ≥95th percentile and 30 healthy children with a BMI ranging from the 5th to the 85th percentile. Healthy and obese children had similar age, gender and pubertal stage distribution. Anthropometric and biochemical parameters (fasting glucose, insulin, lipid profile, leptin and irisin levels) were measured. Bioelectric impedance analysis was used to determine the body composition parameters, including body fat percentage and fat mass. RESULTS: Serum irisin and leptin levels of the obese children were significantly higher than those of the healthy children [median irisin levels, 141.2 & 107.6ng/mL, p=0.024; median leptin levels, 10.9 & 2.9pg/mL, P<0.001, respectively). No statistically significant difference was found when leptin and irisin levels were compared among obese patients in terms of the presence of insulin resistance. Irisin levels significantly correlated with high-density lipoprotein cholesterol (HDL-C), fasting insulin and homeostasis model assessment-insulin resistance (HOMA-IR) with adjustment for age and BMI. The multivariate regression analysis showed that age, HOMA-IR and HDL-C had a significant association with the serum irisin level, which explained 30.6% of the variance. CONCLUSION: This study demonstrated that obese children had significantly higher irisin levels than healthy children. Additionally, it provides evidence regarding the role of irisin on insulin sensitivity and lipid metabolism in childhood obesity.
OBJECTIVE: This study aimed to investigate the relationship between serum irisin level and metabolic and anthropometric parameters in obesechildren. METHODS: The study included 36 obesechildren with a body mass index (BMI) of ≥95th percentile and 30 healthy children with a BMI ranging from the 5th to the 85th percentile. Healthy and obesechildren had similar age, gender and pubertal stage distribution. Anthropometric and biochemical parameters (fasting glucose, insulin, lipid profile, leptin and irisin levels) were measured. Bioelectric impedance analysis was used to determine the body composition parameters, including body fat percentage and fat mass. RESULTS: Serum irisin and leptin levels of the obesechildren were significantly higher than those of the healthy children [median irisin levels, 141.2 & 107.6ng/mL, p=0.024; median leptin levels, 10.9 & 2.9pg/mL, P<0.001, respectively). No statistically significant difference was found when leptin and irisin levels were compared among obesepatients in terms of the presence of insulin resistance. Irisin levels significantly correlated with high-density lipoprotein cholesterol (HDL-C), fasting insulin and homeostasis model assessment-insulin resistance (HOMA-IR) with adjustment for age and BMI. The multivariate regression analysis showed that age, HOMA-IR and HDL-C had a significant association with the serum irisin level, which explained 30.6% of the variance. CONCLUSION: This study demonstrated that obesechildren had significantly higher irisin levels than healthy children. Additionally, it provides evidence regarding the role of irisin on insulin sensitivity and lipid metabolism in childhood obesity.
Authors: S E Beray; M E Atabek; Y Kücükkagnici; S Kurban; M B Selver; M S Iyisoy Journal: Acta Endocrinol (Buchar) Date: 2022 Jan-Mar Impact factor: 1.104
Authors: Leticia Elizondo-Montemayor; Christian Silva-Platas; Alejandro Torres-Quintanilla; Carlos Rodríguez-López; Guillermo U Ruiz-Esparza; Eric Reyes-Mendoza; Gerardo Garcia-Rivas Journal: Biomed Res Int Date: 2017-05-03 Impact factor: 3.411
Authors: Adrian M Gonzalez-Gil; Mariana Peschard-Franco; Elena C Castillo; Gustavo Gutierrez-DelBosque; Victor Treviño; Christian Silva-Platas; Luisa Perez-Villarreal; Gerardo Garcia-Rivas; Leticia Elizondo-Montemayor Journal: Diabetol Metab Syndr Date: 2019-08-05 Impact factor: 3.320