| Literature DB >> 27539584 |
De-Yang Shen1, Ping-Chung Kuo1, Shiow-Chyn Huang2, Tsong-Long Hwang3,4,5, Yu-Yi Chan6, Po-Chuen Shieh7, Nguyen Thi Ngan8, Tran Dinh Thang8, Tian-Shung Wu9,10.
Abstract
Five new acyclic amides, clausenalansamides C-G (1-5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1-5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.Entities:
Keywords: Anti-inflammatory; Clausenalansamide; Electronic circular dichroism; Single-crystal X-ray diffraction analysis; Superoxide anion generation
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Year: 2016 PMID： 27539584 DOI： 10.1007/s11418-016-1033-x
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343