Literature DB >> 27539538

Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders.

Miroslav Adzic1, Zeljka Brkic1, Sonja Bulajic2, Milos Mitic1, Marija B Radojcic1.   

Abstract

Preclinical Research Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016.
© 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Entities:  

Keywords:  antidepressants; brain energy metabolism; intracellular signaling; mitochondria; psychiatric disorders

Mesh：

Substances：

Year:  2016        PMID： 27539538     DOI： 10.1002/ddr.21332

Source DB:  PubMed          Journal:  Drug Dev Res        ISSN： 0272-4391            Impact factor:   4.360


  15 in total

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3.  High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression.

Authors:  Olga Tymofiyeva; Eva Henje Blom; Tiffany C Ho; Colm G Connolly; Daniel Lindqvist; Owen M Wolkowitz; Jue Lin; Kaja Z LeWinn; Matthew D Sacchet; Laura K M Han; Justin P Yuan; Sarina P Bhandari; Duan Xu; Tony T Yang
Journal:  J Affect Disord       Date:  2018-02-17       Impact factor: 4.839

4.  Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling.

Authors:  Vibhor Kumar; Jonathan Aow; Naghmeh Rastegar; Michelle Gek Liang Lim; Nicholas O'Toole; Nirmala Arul Rayan; Edita Aliwarga; Danusa Mar Arcego; Hui Ting Grace Yeo; Jen Yi Wong; May Yin Lee; Florian Schmidt; Hajira Shreen Haja; Wai Leong Tam; Tie-Yuan Zhang; Josie Diorio; Christoph Anacker; Rene Hen; Carine Parent; Michael J Meaney; Shyam Prabhakar
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5.  Stress and Psychiatric Disorders: The Role of Mitochondria.

Authors:  Teresa E Daniels; Elizabeth M Olsen; Audrey R Tyrka
Journal:  Annu Rev Clin Psychol       Date:  2020-02-24       Impact factor: 18.561

Review 6.  Psychiatric drugs impact mitochondrial function in brain and other tissues.

Authors:  Shawna T Chan; Michael J McCarthy; Marquis P Vawter
Journal:  Schizophr Res       Date:  2019-11-16       Impact factor: 4.939

7.  IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids.

Authors:  E Martín-Montañez; C Millon; F Boraldi; F Garcia-Guirado; C Pedraza; E Lara; L J Santin; J Pavia; M Garcia-Fernandez
Journal:  Redox Biol       Date:  2017-05-26       Impact factor: 11.799

8.  New insights into the intracellular distribution pattern of cationic amphiphilic drugs.

Authors:  Magdalena Vater; Leonhard Möckl; Vanessa Gormanns; Carsten Schultz Fademrecht; Anna M Mallmann; Karolina Ziegart-Sadowska; Monika Zaba; Marie L Frevert; Christoph Bräuchle; Florian Holsboer; Theo Rein; Ulrike Schmidt; Thomas Kirmeier
Journal:  Sci Rep       Date:  2017-03-10       Impact factor: 4.379

Review 9.  Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression.

Authors:  Josh Allen; Raquel Romay-Tallon; Kyle J Brymer; Hector J Caruncho; Lisa E Kalynchuk
Journal:  Front Neurosci       Date:  2018-06-06       Impact factor: 4.677

Review 10.  The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment.

Authors:  Anna Giménez-Palomo; Seetal Dodd; Gerard Anmella; Andre F Carvalho; Giselli Scaini; Joao Quevedo; Isabella Pacchiarotti; Eduard Vieta; Michael Berk
Journal:  Front Psychiatry       Date:  2021-07-06       Impact factor: 4.157
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