L Vela1, J C Martínez Castrillo2, P García Ruiz3, C Gasca-Salas4, Y Macías Macías5, E Pérez Fernández5, I Ybot6, E Lopez Valdés7, M M Kurtis8, I J Posada Rodriguez9, M Mata10, C Ruiz Huete11, M Eimil12, C Borrue13, J Del Val3, L López-Manzanares14, A Rojo Sebastian15, R Marasescu16. 1. Department of Neurology, Hospital Fundacion Alcorcón, Madrid, Spain. Electronic address: lvela@fhalcorcon.es. 2. Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain. 3. Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain. 4. M CINAC- Hospital U HM Puerta del Sur, Mostoles. Universidad CEU San Pablo, Madrid, Spain. 5. Department of Neurology, Hospital Fundacion Alcorcón, Madrid, Spain. 6. Department of Neurology, Hospital U La Paz, Madrid, Spain. 7. Department of Neurology, Hospital Clínico San Carlos, Madrid, Spain. 8. Department of Neurology, Hospital Ruber Internacional, Madrid, Spain. 9. Department of Neurology, Hospital 12 de Octubre, Madrid, Spain. 10. Department of Neurology, Hospital Puerta de Hierro, Madrid, Spain. 11. Department of Neurology, Hospital Nuestra Señora del Rosario, Madrid, Spain. 12. Department of Neurology, Hospital de Torrejón, Madrid, Spain. 13. Department of Neurology, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain. 14. Department of Neurology, Hospital de la Princesa, Madrid, Spain. 15. Department of Neurology, Hospital Príncipe de Asturias - Alcalá de Henares, Madrid, Spain. 16. Department of Neurology, Hospital de Getafe, Madrid, Spain.
Abstract
INTRODUCTION: In Parkinson's disease patients, impulse control disorders (ICDs) have been associated with younger age and early disease onset, yet the prevalence of ICDs in early-onset Parkinson's disease (EOPD) patients has yet to be studied. Thus, we set out to compare the prevalence of impulse control behaviors (ICBs) in a cohort of EOPD patients with that in age and gender matched healthy controls (HCs), as well as to analyze the association of these symptoms with the use of dopaminergic drugs and other clinical or demographic factors. METHODS: A cross-sectional, multicenter study was carried out on patients recruited from outpatient Movement Disorder Clinics, assessing ICBs using the short form of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP). In addition, depression and quality of life (QoL) were measured, along with other demographic and clinical variables. RESULTS: Of the 87 EOPD patients, 49 (58.3%) displayed an ICB, as did 28 of the 87 HCs (32.9%; p=0.001). Most of the EOPD patients that displayed an ICB (91.8%) were medicated with a dopamine agonist (DA) and accordingly, DA treatment was associated with a 7-fold increased risk of developing an ICB. Patients with ICBs had a higher depression score and a worse QoL. CONCLUSIONS: ICBs are much more prevalent in EOPD patients than in HCs and they are associated with DA intake, depression and a worse QoL.
INTRODUCTION: In Parkinson's diseasepatients, impulse control disorders (ICDs) have been associated with younger age and early disease onset, yet the prevalence of ICDs in early-onset Parkinson's disease (EOPD) patients has yet to be studied. Thus, we set out to compare the prevalence of impulse control behaviors (ICBs) in a cohort of EOPD patients with that in age and gender matched healthy controls (HCs), as well as to analyze the association of these symptoms with the use of dopaminergic drugs and other clinical or demographic factors. METHODS: A cross-sectional, multicenter study was carried out on patients recruited from outpatientMovement Disorder Clinics, assessing ICBs using the short form of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP). In addition, depression and quality of life (QoL) were measured, along with other demographic and clinical variables. RESULTS: Of the 87 EOPD patients, 49 (58.3%) displayed an ICB, as did 28 of the 87 HCs (32.9%; p=0.001). Most of the EOPD patients that displayed an ICB (91.8%) were medicated with a dopamine agonist (DA) and accordingly, DA treatment was associated with a 7-fold increased risk of developing an ICB. Patients with ICBs had a higher depression score and a worse QoL. CONCLUSIONS:ICBs are much more prevalent in EOPD patients than in HCs and they are associated with DA intake, depression and a worse QoL.
Authors: C Requejo; J A Ruiz-Ortega; H Cepeda; A Sharma; H S Sharma; A Ozkizilcik; R Tian; H Moessler; L Ugedo; J V Lafuente Journal: Mol Neurobiol Date: 2018-01 Impact factor: 5.590
Authors: Paloma Parra-Díaz; Juan Luis Chico-García; Álvaro Beltrán-Corbellini; Fernando Rodríguez-Jorge; Clara Lastras Fernández-Escandón; Araceli Alonso-Cánovas; Juan Carlos Martínez-Castrillo Journal: Mov Disord Clin Pract Date: 2020-12-21
Authors: Alice Martini; Denise Dal Lago; Nicola M J Edelstyn; James A Grange; Stefano Tamburin Journal: Front Neurol Date: 2018-08-28 Impact factor: 4.003