Literature DB >> 27538359

Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery.

Yilong Cheng1, Roma C Yumul1, Suzie H Pun2.   

Abstract

Clinical translation of nucleic acids drugs has been stunted by limited delivery options. Herein, we report a synthetic polymer designed to mimic viral mechanisms of delivery called VIPER (virus-inspired polymer for endosomal release). VIPER is composed of a polycation block for condensation of nucleic acids, and a pH-sensitive block for acid-triggered display of a lytic peptide to promote trafficking to the cell cytosol. VIPER shows superior efficiencies compared to commercial agents when delivering genes to multiple immortalized cell lines. Importantly, in murine models, VIPER facilitates effective gene transfer to solid tumors.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  DNA release; VIPER; gene delivery; melittin; virus-inspired polymers

Mesh：

Substances：

Year:  2016        PMID： 27538359      PMCID： PMC5034564          DOI： 10.1002/anie.201605958

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  32 in total

1.  Functional genetic and biophysical analyses of membrane disruption by human adenovirus.

Authors:  Crystal L Moyer; Christopher M Wiethoff; Oana Maier; Jason G Smith; Glen R Nemerow
Journal:  J Virol       Date:  2011-01-05       Impact factor: 5.103

2.  Analysis of the intracellular barriers encountered by nonviral gene carriers in a model of spatially controlled delivery to neurons.

Authors:  Jamie M Bergen; Suzie H Pun
Journal:  J Gene Med       Date:  2008-02       Impact factor: 4.565

Review 3.  Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond).

Authors:  Ulrich Lächelt; Ernst Wagner
Journal:  Chem Rev       Date:  2015-04-15       Impact factor: 60.622

Review 4.  Non-viral vectors for gene-based therapy.

Authors:  Hao Yin; Rosemary L Kanasty; Ahmed A Eltoukhy; Arturo J Vegas; J Robert Dorkin; Daniel G Anderson
Journal:  Nat Rev Genet       Date:  2014-07-15       Impact factor: 53.242

5.  Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.

Authors:  Mark E Davis; Jonathan E Zuckerman; Chung Hang J Choi; David Seligson; Anthony Tolcher; Christopher A Alabi; Yun Yen; Jeremy D Heidel; Antoni Ribas
Journal:  Nature       Date:  2010-03-21       Impact factor: 49.962

6.  Enhanced Performance of Plasmid DNA Polyplexes Stabilized by a Combination of Core Hydrophobicity and Surface PEGylation.

Authors:  Elizabeth J Adolph; Christopher E Nelson; Thomas A Werfel; Ruijing Guo; Jeffrey M Davidson; Scott A Guelcher; Craig L Duvall
Journal:  J Mater Chem B       Date:  2014-12-14       Impact factor: 6.331

7.  Application of an HIV gp41-derived peptide for enhanced intracellular trafficking of synthetic gene and siRNA delivery vehicles.

Authors:  Ester J Kwon; Jamie M Bergen; Suzie H Pun
Journal:  Bioconjug Chem       Date:  2008-04-01       Impact factor: 4.774

8.  Development of a novel endosomolytic diblock copolymer for siRNA delivery.

Authors:  Anthony J Convertine; Danielle S W Benoit; Craig L Duvall; Allan S Hoffman; Patrick S Stayton
Journal:  J Control Release       Date:  2008-10-17       Impact factor: 9.776

9.  Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes.

Authors:  You-Yeon Won; Rahul Sharma; Stephen F Konieczny
Journal:  J Control Release       Date:  2009-07-04       Impact factor: 9.776

10.  A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals.

Authors:  Yiguang Wang; Kejin Zhou; Gang Huang; Christopher Hensley; Xiaonan Huang; Xinpeng Ma; Tian Zhao; Baran D Sumer; Ralph J DeBerardinis; Jinming Gao
Journal:  Nat Mater       Date:  2013-12-08       Impact factor: 43.841
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  24 in total

1.  Cationic polymers for non-viral gene delivery to human T cells.

Authors:  Brynn R Olden; Yilong Cheng; Jonathan L Yu; Suzie H Pun
Journal:  J Control Release       Date:  2018-03-05       Impact factor: 9.776

2.  Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers.

Authors:  Yilong Cheng; Drew L Sellers; James-Kevin Y Tan; David J Peeler; Philip J Horner; Suzie H Pun
Journal:  Biomaterials       Date:  2017-03-01       Impact factor: 12.479

3.  INVENTION IS NOT AN OPTION.

Authors:  Yolanda L Comedy; Juan E Gilbert; Suzie H Pun
Journal:  Technol Innov       Date:  2017-03-01

4.  Identifying key barriers in cationic polymer gene delivery to human T cells.

Authors:  Brynn R Olden; Emmeline Cheng; Yilong Cheng; Suzie H Pun
Journal:  Biomater Sci       Date:  2019-02-26       Impact factor: 6.843

Review 5.  Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles.

Authors:  Adeel Masood Butt; Nabiha Abdullah; Nur Najihah Izzati Mat Rani; Naveed Ahmad; Mohd Cairul Iqbal Mohd Amin
Journal:  Pharm Res       Date:  2022-05-26       Impact factor: 4.200

6.  Polyplex transfection from intracerebroventricular delivery is not significantly affected by traumatic brain injury.

Authors:  David J Peeler; Nicholas Luera; Philip J Horner; Suzie H Pun; Drew L Sellers
Journal:  J Control Release       Date:  2020-03-18       Impact factor: 9.776

Review 7.  T-cell targeted pulmonary siRNA delivery for the treatment of asthma.

Authors:  Tobias W M Keil; Domizia Baldassi; Olivia M Merkel
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2020-04-08

8.  Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice.

Authors:  Meilyn Sylvestre; Shixian Lv; Lucy F Yang; Nicholas Luera; David J Peeler; Bing-Mae Chen; Steve R Roffler; Suzie H Pun
Journal:  J Control Release       Date:  2021-01-11       Impact factor: 9.776

9.  Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing.

Authors:  Shuai Liu; Qiang Cheng; Tuo Wei; Xueliang Yu; Lindsay T Johnson; Lukas Farbiak; Daniel J Siegwart
Journal:  Nat Mater       Date:  2021-02-04       Impact factor: 47.656

10.  In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells.

Authors:  Daniel P Feldmann; Yilong Cheng; Rima Kandil; Yuran Xie; Mariam Mohammadi; Hartmann Harz; Akhil Sharma; David J Peeler; Anna Moszczynska; Heinrich Leonhardt; Suzie H Pun; Olivia M Merkel
Journal:  J Control Release       Date:  2018-02-20       Impact factor: 9.776
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