P Liu1,2, L Xu3, Y Wang2, Y Zhang2, Y Du1, Y Sun1, Z Wang4. 1. Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Shandong, China. 2. Division of Epidemiology Survey, China Animal Health and Epidemiology Center, Ministry of Agriculture, Beijing, China. 3. Department of Health, Jinan Maternal and Child Care Service Centre, Shandong, China. 4. Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Shandong, China. zhipingw@sdu.edu.cn.
Abstract
OBJECTIVE: To quantify the association between maternal pre-pregnancy body mass index (BMI) and perinatal outcomes. METHODS: We systematically reviewed and collected studies on maternal pre-pregnancy BMI and perinatal outcomes published up to 31 August 2015. For each study, we constructed separate two-by-two tables to calculate the odds ratios (ORs) and 95% confidence intervals (CI). RESULTS: A total of 60 studies involving 1,392,799 women were included, and the proportions of obesity, overweight, normal weight and underweight pregnant women were 11.72%, 22.08%, 58.03% and 8.18%, respectively. When mothers were overweight or obese, their infants had a significantly higher risk of being large for gestational age (OR, 1.45, 95%CI, 1.29-1.63 and 1.88, 95%CI, 1.67-2.11, respectively), having macrosomia (OR, 1.70, 95%CI, 1.55-1.87 and 2.92, 95%CI, 2.67-3.20, respectively), being admitted to the neonatal intensive care unit (OR, 1.29, 95%CI, 1.12-1.48 and 1.91, 95%CI, 1.60-2.29, respectively) and being stillborn (OR, 1.27, 95%CI, 1.18-1.36 and 1.81, 95%CI, 1.69-1.93, respectively). When mothers were underweight, their infants had a lower risk of the aforementioned outcomes. However, mothers who were underweight had a higher risk of preterm birth (OR, 1.30, 95%CI, 1.13-1.49) and delivering an infant small for gestational age (OR, 1.67, 95%CI, 1.49-1.87). Importantly, infants had a higher risk of having a low birth weight (LBW) when their mothers were underweight (OR, 1.67, 95%CI, 1.39-2.02) or obese (OR, 1.24, 95%CI, 1.09-1.41). CONCLUSION: Being overweight or obese was associated with an increased risk of still birth, large for gestational age, macrosomia, admission to the neonatal intensive care unit and LBW, while being underweight was associated with an increased risk of preterm birth, small for gestational age, and LBW. Women of childbearing age should maintain a normal body mass index before pregnancy.
OBJECTIVE: To quantify the association between maternal pre-pregnancy body mass index (BMI) and perinatal outcomes. METHODS: We systematically reviewed and collected studies on maternal pre-pregnancy BMI and perinatal outcomes published up to 31 August 2015. For each study, we constructed separate two-by-two tables to calculate the odds ratios (ORs) and 95% confidence intervals (CI). RESULTS: A total of 60 studies involving 1,392,799 women were included, and the proportions of obesity, overweight, normal weight and underweight pregnant women were 11.72%, 22.08%, 58.03% and 8.18%, respectively. When mothers were overweight or obese, their infants had a significantly higher risk of being large for gestational age (OR, 1.45, 95%CI, 1.29-1.63 and 1.88, 95%CI, 1.67-2.11, respectively), having macrosomia (OR, 1.70, 95%CI, 1.55-1.87 and 2.92, 95%CI, 2.67-3.20, respectively), being admitted to the neonatal intensive care unit (OR, 1.29, 95%CI, 1.12-1.48 and 1.91, 95%CI, 1.60-2.29, respectively) and being stillborn (OR, 1.27, 95%CI, 1.18-1.36 and 1.81, 95%CI, 1.69-1.93, respectively). When mothers were underweight, their infants had a lower risk of the aforementioned outcomes. However, mothers who were underweight had a higher risk of preterm birth (OR, 1.30, 95%CI, 1.13-1.49) and delivering an infant small for gestational age (OR, 1.67, 95%CI, 1.49-1.87). Importantly, infants had a higher risk of having a low birth weight (LBW) when their mothers were underweight (OR, 1.67, 95%CI, 1.39-2.02) or obese (OR, 1.24, 95%CI, 1.09-1.41). CONCLUSION: Being overweight or obese was associated with an increased risk of still birth, large for gestational age, macrosomia, admission to the neonatal intensive care unit and LBW, while being underweight was associated with an increased risk of preterm birth, small for gestational age, and LBW. Women of childbearing age should maintain a normal body mass index before pregnancy.
Authors: Bao-Ying Feng; Yang Peng; Jun Liang; Li Wu; Qun-Jiao Jiang; Shun Liu; Xiao-Yun Zeng; Dong-Ping Huang; Xiao-Qiang Qiu; Han Li Journal: Curr Med Sci Date: 2021-04-20
Authors: Nelson D Pace; Anna Maria Siega-Riz; Andrew F Olshan; Nancy C Chescheir; Stephen R Cole; Tania A Desrosiers; Sarah C Tinker; Adrienne T Hoyt; Mark A Canfield; Suzan L Carmichael; Robert E Meyer Journal: Birth Defects Res Date: 2019-07-19 Impact factor: 2.344
Authors: Buyun Liu; Guifeng Xu; Yangbo Sun; Yang Du; Rui Gao; Linda G Snetselaar; Mark K Santillan; Wei Bao Journal: Lancet Diabetes Endocrinol Date: 2019-08-05 Impact factor: 32.069
Authors: Shayna D Cunningham; Shilpa Mokshagundam; Hannah Chai; Jessica B Lewis; Jessica Levine; Jonathan N Tobin; Jeannette R Ickovics Journal: J Midwifery Womens Health Date: 2018-03-23 Impact factor: 2.388