Yi Guan1, Chuan-Ming Hao1. 1. Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Abstract
BACKGROUND: SIRT1 is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases. Abundantly expressed in the kidney, especially in the renal medulla, SIRT1 is closely involved in renal physiology and pathology. SUMMARY: SIRT1 targets both histone and nonhistone proteins, participates in many important signaling pathways and mediates the regulation of longevity, metabolic homeostasis, acute stress response and DNA integrity. With regard to the kidney, SIRT1 attenuates diabetic albuminuria, reduces blood pressure and related cardiovascular diseases, resists acute kidney injury, delays kidney fibrogenesis, promotes cyst formation and benefits renal ageing. KEY MESSAGES: This review summarizes the biology of SIRT1 and focuses on the latest studies concerning SIRT1 as a potential therapeutic target for kidney diseases.
BACKGROUND:SIRT1 is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases. Abundantly expressed in the kidney, especially in the renal medulla, SIRT1 is closely involved in renal physiology and pathology. SUMMARY:SIRT1 targets both histone and nonhistone proteins, participates in many important signaling pathways and mediates the regulation of longevity, metabolic homeostasis, acute stress response and DNA integrity. With regard to the kidney, SIRT1 attenuates diabetic albuminuria, reduces blood pressure and related cardiovascular diseases, resists acute kidney injury, delays kidney fibrogenesis, promotes cyst formation and benefits renal ageing. KEY MESSAGES: This review summarizes the biology of SIRT1 and focuses on the latest studies concerning SIRT1 as a potential therapeutic target for kidney diseases.
Authors: Radovan Vasko; Sandhya Xavier; Jun Chen; Chi Hua Sarah Lin; Brian Ratliff; May Rabadi; Julien Maizel; Rina Tanokuchi; Frank Zhang; Jian Cao; Michael S Goligorsky Journal: J Am Soc Nephrol Date: 2013-10-17 Impact factor: 10.121
Authors: Malgorzata Karbowska; Tomasz W Kaminski; Beata Znorko; Tomasz Domaniewski; Tomasz Misztal; Tomasz Rusak; Anna Pryczynicz; Katarzyna Guzinska-Ustymowicz; Krystyna Pawlak; Dariusz Pawlak Journal: Front Physiol Date: 2018-11-28 Impact factor: 4.566