Literature DB >> 27535735

HELLP syndrome: a diagnostic conundrum with severe complications.

Devika Rao1, Nikulkumar Kumar Chaudhari2, Robert Michael Moore3, Belinda Jim1.   

Abstract

The HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome is believed to be part of the spectrum of pre-eclampsia, which falls within the category of hypertensive disorders of pregnancy. Maternal and fetal complications are more severe in HELLP as opposed to pre-eclampsia alone. We describe a 26-year-old primigravida woman with no medical history who presents with signs of HELLP with marked transaminitis and mild disseminated intravascular coagulation at 35 weeks of gestation who required emergent delivery of the fetus; the patient also sustained acute kidney injury requiring continuous veno-venous hemodiafiltration and a prolonged intensive care unit admission. Remarkably, with supportive care, all laboratory derangements, including renal function, normalised after 4 weeks. We discuss the diagnostic conundrum when faced with the possible diagnosis of HELLP in discriminating from its many imitators in order to assume proper treatment. 2016 BMJ Publishing Group Ltd.

Entities:  

Mesh:

Year:  2016        PMID: 27535735      PMCID: PMC5015173          DOI: 10.1136/bcr-2016-216802

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  30 in total

Review 1.  Differentiation between severe HELLP syndrome and thrombotic microangiopathy, thrombotic thrombocytopenic purpura and other imitators.

Authors:  O Pourrat; R Coudroy; F Pierre
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2015-03-25       Impact factor: 2.435

Review 2.  Atypical hemolytic-uremic syndrome.

Authors:  Marina Noris; Giuseppe Remuzzi
Journal:  N Engl J Med       Date:  2009-10-22       Impact factor: 91.245

3.  Disseminated intravascular coagulation and the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia.

Authors:  P A Van Dam; M Renier; M Baekelandt; P Buytaert; F Uyttenbroeck
Journal:  Obstet Gynecol       Date:  1989-01       Impact factor: 7.661

4.  Eculizumab in pregnancy-associated atypical hemolytic uremic syndrome: insights for optimizing management.

Authors:  Erika De Sousa Amorim; Miquel Blasco; Luis Quintana; Manel Sole; Santiago Rodríguez de Cordoba; Josep Maria Campistol
Journal:  J Nephrol       Date:  2015-02-25       Impact factor: 3.902

Review 5.  Imitators of preeclampsia: A review.

Authors:  Adam Morton
Journal:  Pregnancy Hypertens       Date:  2016-02-22       Impact factor: 2.899

6.  Acute fatty liver and HELLP syndrome: two distinct pregnancy disorders.

Authors:  P Vigil-De Gracia
Journal:  Int J Gynaecol Obstet       Date:  2001-06       Impact factor: 3.561

7.  Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure.

Authors:  James N Martin; Brad D Thigpen; Robert C Moore; Carl H Rose; Julie Cushman; Warren May
Journal:  Obstet Gynecol       Date:  2005-02       Impact factor: 7.661

8.  Milestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia).

Authors:  James Nello Martin
Journal:  Int J Gynaecol Obstet       Date:  2013-03-23       Impact factor: 3.561

9.  Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)

Authors:  B M Sibai; M K Ramadan; I Usta; M Salama; B M Mercer; S A Friedman
Journal:  Am J Obstet Gynecol       Date:  1993-10       Impact factor: 8.661

10.  Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy.

Authors:  L Weinstein
Journal:  Am J Obstet Gynecol       Date:  1982-01-15       Impact factor: 8.661

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  1 in total

1.  A Case of Acute Pancreatitis in Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome.

Authors:  Manuel Pereira Herrera; Joshua B Oaks; Jeffrey Brensilver
Journal:  Cureus       Date:  2018-06-25
  1 in total

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