M E Mast1, M W Heijenbrok2, M L van Kempen-Harteveld3, A L Petoukhova3, A N Scholten4, R Wolterbeek5, J H M Schreur6, H Struikmans3,7. 1. Radiotherapy, Centre West, Lijnbaan 32, 2501 CK, The Hague, The Netherlands. m.mast@mchaaglanden.nl. 2. Department of radiology, Medical Center Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands. 3. Radiotherapy, Centre West, Lijnbaan 32, 2501 CK, The Hague, The Netherlands. 4. Department of Radiation Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. 5. Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. 6. Department of Cardiology, Medical Center Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands. 7. Department of Clinical Oncology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
Abstract
PURPOSE: The aim of this prospective longitudinal study was to compare coronary artery calcium (CAC) scores determined before the start of whole breast irradiation with those determined 3 years afterwards. PATIENTS AND METHODS: Changes in CAC scores were analysed in 99 breast cancer patients. Three groups were compared: patients receiving left- and right-sided radiotherapy, and those receiving left-sided radiotherapy with breath-hold. We analysed overall CAC scores and left anterior descending (LAD) and right coronary artery (RCA) CAC scores. Between the three groups, changes of the value of the LAD minus the RCA CAC scores of each individual patient were also compared. RESULTS: Three years after breath-hold-based whole breast irradiation, a less pronounced increase of CAC scores was noted. Furthermore, LAD minus RCA scores in patients treated for left-sided breast cancer without breath-hold were higher when compared to LAD minus RCA scores of patients with right-sided breast cancers and those with left-sided breast cancer treated with breath-hold. CONCLUSION: Breath-hold in breast-conserving radiotherapy leads to a less pronounced increase of CT-based CAC scores. Therefore, breath-hold probably prevents the development of radiation-induced coronary artery disease. However, the sample size of this study is limited and the follow-up period relatively short.
PURPOSE: The aim of this prospective longitudinal study was to compare coronary artery calcium (CAC) scores determined before the start of whole breast irradiation with those determined 3 years afterwards. PATIENTS AND METHODS: Changes in CAC scores were analysed in 99 breast cancerpatients. Three groups were compared: patients receiving left- and right-sided radiotherapy, and those receiving left-sided radiotherapy with breath-hold. We analysed overall CAC scores and left anterior descending (LAD) and right coronary artery (RCA) CAC scores. Between the three groups, changes of the value of the LAD minus the RCA CAC scores of each individual patient were also compared. RESULTS: Three years after breath-hold-based whole breast irradiation, a less pronounced increase of CAC scores was noted. Furthermore, LAD minus RCA scores in patients treated for left-sided breast cancer without breath-hold were higher when compared to LAD minus RCA scores of patients with right-sided breast cancers and those with left-sided breast cancer treated with breath-hold. CONCLUSION: Breath-hold in breast-conserving radiotherapy leads to a less pronounced increase of CT-based CAC scores. Therefore, breath-hold probably prevents the development of radiation-induced coronary artery disease. However, the sample size of this study is limited and the follow-up period relatively short.
Authors: Philip Greenland; Robert O Bonow; Bruce H Brundage; Matthew J Budoff; Mark J Eisenberg; Scott M Grundy; Michael S Lauer; Wendy S Post; Paolo Raggi; Rita F Redberg; George P Rodgers; Leslee J Shaw; Allen J Taylor; William S Weintraub; Robert A Harrington; Jonathan Abrams; Jeffrey L Anderson; Eric R Bates; Cindy L Grines; Mark A Hlatky; Robert C Lichtenberg; Jonathan R Lindner; Gerald M Pohost; Richard S Schofield; Samuel J Shubrooks; James H Stein; Cynthia M Tracy; Robert A Vogel; Deborah J Wesley Journal: Circulation Date: 2007-01-12 Impact factor: 29.690
Authors: Fiona Anne Stewart; Sylvia Heeneman; Johannes Te Poele; Jacqueline Kruse; Nicola S Russell; Marion Gijbels; Mat Daemen Journal: Am J Pathol Date: 2006-02 Impact factor: 4.307
Authors: Matthijs Oudkerk; Arthur E Stillman; Sandra S Halliburton; Willi A Kalender; Stefan Möhlenkamp; Cynthia H McCollough; Rozemarijn Vliegenthart; Leslee J Shaw; William Stanford; Allen J Taylor; Peter M A van Ooijen; Lewis Wexler; Paolo Raggi Journal: Eur Radiol Date: 2008-07-24 Impact factor: 5.315
Authors: Mirjam E Mast; Loes van Kempen-Harteveld; Mark W Heijenbrok; Yamoena Kalidien; Hans Rozema; Wim P A Jansen; Anna L Petoukhova; Henk Struikmans Journal: Radiother Oncol Date: 2013-09-14 Impact factor: 6.280
Authors: Gerben R Borst; Jan-Jakob Sonke; Suzanne den Hollander; Anja Betgen; Peter Remeijer; Aline van Giersbergen; Nicola S Russell; Paula H M Elkhuizen; Harry Bartelink; Corine van Vliet-Vroegindeweij Journal: Int J Radiat Oncol Biol Phys Date: 2010-03-06 Impact factor: 7.038
Authors: Greger Nilsson; Lars Holmberg; Hans Garmo; Olov Duvernoy; Iwar Sjögren; Bo Lagerqvist; Carl Blomqvist Journal: J Clin Oncol Date: 2011-12-27 Impact factor: 44.544
Authors: Stefanie Corradini; Hendrik Ballhausen; Helmut Weingandt; Philipp Freislederer; Stephan Schönecker; Maximilian Niyazi; Cristoforo Simonetto; Markus Eidemüller; Ute Ganswindt; Claus Belka Journal: Strahlenther Onkol Date: 2017-09-15 Impact factor: 3.621
Authors: Raimund H M Preidl; Patrick Möbius; Manuel Weber; Kerstin Amann; Friedrich W Neukam; Marco Kesting; Carol-Immanuel Geppert; Falk Wehrhan Journal: Strahlenther Onkol Date: 2018-10-15 Impact factor: 3.621
Authors: Valentin Walker; Anne Crijns; Johannes Langendijk; Daan Spoor; Rozemarijn Vliegenthart; Stephanie E Combs; Michael Mayinger; Arantxa Eraso; Ferran Guedea; Manuela Fiuza; Susana Constantino; Radia Tamarat; Dominique Laurier; Jean Ferrières; Elie Mousseaux; Elisabeth Cardis; Sophie Jacob Journal: JMIR Res Protoc Date: 2018-10-01