Seung-Kuk Baek1, Myung-Chul Lee2, J Hun Hah3, Soon-Hyun Ahn4, Young-Ik Son5, Young-Soo Rho6, Phil-Sang Chung7, Yoon-Se Lee8, Bon Seok Koo9, Kwang-Yoon Jung1, Byung-Joo Lee10. 1. Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea. 2. Department of Otolaryngology - Head and Neck Surgery, Korea Cancer Center Hospital, Seoul, Korea. 3. Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea. 4. Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul, Korea. 5. Department of Otorhinolaryngology - Head and Neck Surgery, Sungkyunkwan University School of Medicine, Gyeonggi-do, Korea. 6. Department of Otorhinolaryngology - Head and Neck Surgery, Hallym University College of Medicine, Gangwon-do, Korea. 7. Department of Otorhinolaryngology - Head and Neck Surgery, Dankook University College of Medicine, Chungnam, Korea. 8. Department of Otorhinolaryngology - Head and Neck Surgery, Ulsan University College of Medicine, Seoul, Korea. 9. Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, 305-764, Korea. 10. Department of Otorhinolaryngology - Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Busan, Korea.
Abstract
BACKGROUND: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. METHODS: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. RESULTS: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). CONCLUSION: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.
BACKGROUND: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. METHODS: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. RESULTS: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). CONCLUSION: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.
Authors: Pascal K C Jonker; John Turchini; Schelto Kruijff; Jia Feng Lin; Anthony J Gill; Thomas Eade; Ahmad Ahniss; Roderick Clifton-Bligh; Diana Learoyd; Bruce Robinson; Venessa Tsang; Anthony Glover; Stanley Sidhu; Mark Sywak Journal: Ann Surg Oncol Date: 2021-05-25 Impact factor: 5.344
Authors: Kelsey L Corrigan; Hannah Williamson; Danielle Elliott Range; Donna Niedzwiecki; David M Brizel; Yvonne M Mowery Journal: J Thyroid Res Date: 2019-05-23
Authors: Keith C Bible; Electron Kebebew; James Brierley; Juan P Brito; Maria E Cabanillas; Thomas J Clark; Antonio Di Cristofano; Robert Foote; Thomas Giordano; Jan Kasperbauer; Kate Newbold; Yuri E Nikiforov; Gregory Randolph; M Sara Rosenthal; Anna M Sawka; Manisha Shah; Ashok Shaha; Robert Smallridge; Carol K Wong-Clark Journal: Thyroid Date: 2021-03 Impact factor: 6.568