Literature DB >> 27533742

Immunosuppressive effect of extracts from leaves of Fraxinus Mandshurica Rupr.

Yujuan Chen1, Gang Xue1, Feizhou Liu2, Xiuling Gong3.   

Abstract

Plants provide a rich resource of medicinal material for research and development of new medicine. To discover new compounds as Immunosuppressant from plants, we evaluated the immunosuppressive effect of different fractions and particularly one compound (Calceolarioside A) that were extracted from the leaves of Fraxinus Mandshurica Rupr. The fractions and the compound were tested on the ability to reduce Immunoglobulin E (IgE) secretion by human U266 multiple myeloma cells (U266 cells) and to reduce interleukin-2 (IL-2) secretion by mouse spleen cells. Our results showed that both the butanol extract fraction and the compound of Calceolarioside A inhibited the IgE and IL-2 production in U266 cells and mouse spleen cells respectively, and no cytotoxicity was observed within the effective dose range. These results suggest that Calceolarioside A could potentially serve as an immunosuppressant.

Entities:  

Keywords:  Calceolarioside A; Fraxinus Mandshurica Rupr; Immunosuppresive effect; U266 cells; spleen cells

Mesh：

Substances：

Year:  2016        PMID： 27533742      PMCID： PMC5470513          DOI： 10.1080/21655979.2016.1221023

Source DB:  PubMed          Journal:  Bioengineered        ISSN： 2165-5979            Impact factor:   3.269


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  6 in total

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