Literature DB >> 27533037

Drug discovery: Designing the ideal opioid.

Brigitte L Kieffer1.   

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Year:  2016        PMID： 27533037     DOI： 10.1038/nature19424

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


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  12 in total

Review 1.  The evasive nature of drug efficacy: implications for drug discovery.

Authors:  Ségolène Galandrin; Geneviève Oligny-Longpré; Michel Bouvier
Journal:  Trends Pharmacol Sci       Date:  2007-07-19       Impact factor: 14.819

Review 2.  Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.

Authors:  Kirsten M Raehal; Cullen L Schmid; Chad E Groer; Laura M Bohn
Journal:  Pharmacol Rev       Date:  2011-08-26       Impact factor: 25.468

Review 3.  Restructuring G-protein- coupled receptor activation.

Authors:  Martin Audet; Michel Bouvier
Journal:  Cell       Date:  2012-09-28       Impact factor: 41.582

Review 4.  Structure-based drug screening for G-protein-coupled receptors.

Authors:  Brian K Shoichet; Brian K Kobilka
Journal:  Trends Pharmacol Sci       Date:  2012-04-13       Impact factor: 14.819

5.  Structure-based discovery of opioid analgesics with reduced side effects.

Authors:  Aashish Manglik; Henry Lin; Dipendra K Aryal; John D McCorvy; Daniela Dengler; Gregory Corder; Anat Levit; Ralf C Kling; Viachaslau Bernat; Harald Hübner; Xi-Ping Huang; Maria F Sassano; Patrick M Giguère; Stefan Löber; Grégory Scherrer; Brian K Kobilka; Peter Gmeiner; Bryan L Roth; Brian K Shoichet
Journal:  Nature       Date:  2016-08-17       Impact factor: 49.962

Review 6.  Exploring the opioid system by gene knockout.

Authors:  Brigitte L Kieffer; Claire Gavériaux-Ruff
Journal:  Prog Neurobiol       Date:  2002-04       Impact factor: 11.685

7.  A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.

Authors:  Scott M DeWire; Dennis S Yamashita; David H Rominger; Guodong Liu; Conrad L Cowan; Thomas M Graczyk; Xiao-Tao Chen; Philip M Pitis; Dimitar Gotchev; Catherine Yuan; Michael Koblish; Michael W Lark; Jonathan D Violin
Journal:  J Pharmacol Exp Ther       Date:  2013-01-08       Impact factor: 4.030

Review 8.  Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics.

Authors:  Tuan Trang; Ream Al-Hasani; Daniela Salvemini; Michael W Salter; Howard Gutstein; Catherine M Cahill
Journal:  J Neurosci       Date:  2015-10-14       Impact factor: 6.167

Review 9.  New G-protein-coupled receptor crystal structures: insights and limitations.

Authors:  Brian Kobilka; Gebhard F X Schertler
Journal:  Trends Pharmacol Sci       Date:  2008-01-14       Impact factor: 14.819

10.  Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.

Authors:  Aashish Manglik; Andrew C Kruse; Tong Sun Kobilka; Foon Sun Thian; Jesper M Mathiesen; Roger K Sunahara; Leonardo Pardo; William I Weis; Brian K Kobilka; Sébastien Granier
Journal:  Nature       Date:  2012-03-21       Impact factor: 49.962
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  5 in total

1.  Inflammation-associated changes in DOR expression and function in the mouse colon.

Authors:  Jesse J DiCello; Ayame Saito; Pradeep Rajasekhar; Emily M Eriksson; Rachel M McQuade; Cameron J Nowell; Benjamin W Sebastian; Jakub Fichna; Nicholas A Veldhuis; Meritxell Canals; Nigel W Bunnett; Simona E Carbone; Daniel P Poole
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-06-21       Impact factor: 4.052

2.  Site-Selective Reaction of Enaminones and Enamine Esters for the Synthesis of Novel Diverse Morphan Derivatives.

Authors:  Xing-Mei Hu; Bei Zhou; Chang-Long Yang; Jun Lin; Sheng-Jiao Yan
Journal:  ACS Omega       Date:  2018-06-04

Review 3.  Recent advances in basic science methodology to evaluate opioid safety profiles and to understand opioid activities.

Authors:  Aliza T Ehrlich; Emmanuel Darcq
Journal:  Fac Rev       Date:  2021-02-19

4.  A Large-Scale Observational Study on the Temporal Trends and Risk Factors of Opioid Overdose: Real-World Evidence for Better Opioids.

Authors:  Jianyuan Deng; Wei Hou; Xinyu Dong; Janos Hajagos; Mary Saltz; Joel Saltz; Fusheng Wang
Journal:  Drugs Real World Outcomes       Date:  2021-05-26

5.  Better agonist for the opioid receptors.

Authors:  Syed Lal Badshah; Asad Ullah; Salim S Al-Showiman; Yahia Nasser Mabkhot
Journal:  Chem Cent J       Date:  2018-02-08       Impact factor: 4.215
  5 in total

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