Literature DB >> 27532060

Mathematical model of the effect of intercellular cooperative interactions in cancer during drug therapy.

Chanchala D Kaddi1, May D Wang2.   

Abstract

We present an agent-based model of head and neck cancer cell population dynamics that investigates the effect of cooperative interactions between individual cancer cells during the course of cytotoxic drug treatment. A model of cooperative behavior based on the Lotka-Volterra competition equations is combined with a model of drug resistance and response. Predictions regarding the individual and combination effects of cooperation and drug treatment qualitatively match experimental observations from the literature.

Entities:  

Year:  2013        PMID： 27532060      PMCID： PMC4983431          DOI： 10.1109/BSEC.2013.6618486

Source DB:  PubMed          Journal:  Annu ORNL Biomed Sci Eng Cent Conf


  13 in total

Review 1.  Evolution of cooperation among tumor cells.

Authors:  Robert Axelrod; David E Axelrod; Kenneth J Pienta
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-28       Impact factor: 11.205

2.  Defining the role of cooperation in early tumor progression.

Authors:  Konstantin Krepkin; José Costa
Journal:  J Theor Biol       Date:  2011-07-02       Impact factor: 2.691

3.  The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue.

Authors:  X Xie; O P Clausen; P De Angelis; M Boysen
Journal:  Cancer       Date:  1999-09-15       Impact factor: 6.860

Review 4.  The molecular biology of head and neck cancer.

Authors:  C René Leemans; Boudewijn J M Braakhuis; Ruud H Brakenhoff
Journal:  Nat Rev Cancer       Date:  2010-12-16       Impact factor: 60.716

Review 5.  Cancer as an evolutionary and ecological process.

Authors:  Lauren M F Merlo; John W Pepper; Brian J Reid; Carlo C Maley
Journal:  Nat Rev Cancer       Date:  2006-11-16       Impact factor: 60.716

6.  2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.

Authors:  Justin L Ricker; Zhong Chen; Xin Ping Yang; Victor S Pribluda; Glenn M Swartz; Carter Van Waes
Journal:  Clin Cancer Res       Date:  2004-12-15       Impact factor: 12.531

7.  Ecological therapy for cancer: defining tumors using an ecosystem paradigm suggests new opportunities for novel cancer treatments.

Authors:  Kenneth J Pienta; Natalie McGregor; Robert Axelrod; David E Axelrod
Journal:  Transl Oncol       Date:  2008-12       Impact factor: 4.243

Review 8.  A "class action" against the microenvironment: do cancer cells cooperate in metastasis?

Authors:  François-Clément Bidard; Jean-Yves Pierga; Anne Vincent-Salomon; Marie-France Poupon
Journal:  Cancer Metastasis Rev       Date:  2008-03       Impact factor: 9.264

9.  Combined evaluation of expression of telomerase, survivin, and anti-apoptotic Bcl-2 family members in relation to loss of differentiation and apoptosis in human head and neck cancers.

Authors:  Himani Sharma; Sudip Sen; Meera Mathur; Sudhir Bahadur; Neeta Singh
Journal:  Head Neck       Date:  2004-08       Impact factor: 3.147

10.  Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.

Authors:  D M Easty; G C Easty; R L Carter; P Monaghan; L J Butler
Journal:  Br J Cancer       Date:  1981-06       Impact factor: 7.640
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